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05419nam a2200589 4500 |
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ocn989872328 |
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OCoLC |
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20180501122036.0 |
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m o d |
| 007 |
cr cnu|||unuuu |
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170612s2017 maua ob 000 0 eng d |
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|a N$T
|b eng
|e rda
|e pn
|c N$T
|d N$T
|d OPELS
|d EBLCP
|d OCLCF
|d YDX
|d OTZ
|d NRC
|d MEU
|d D6H
|d GrThAP
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| 019 |
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|a 990036829
|a 1029494409
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|a 9780128117781
|q (electronic bk.)
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|a 0128117788
|q (electronic bk.)
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|a 9780128117774
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|a 012811777X
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| 035 |
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|a (OCoLC)989872328
|z (OCoLC)990036829
|z (OCoLC)1029494409
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| 050 |
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4 |
|a QH450.25
|b .R634 2017eb
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| 072 |
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7 |
|a SCI
|x 007000
|2 bisacsh
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|a 572.8/8
|2 23
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| 049 |
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|a TEFA
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|a RNA Modification /
|c [edited by] Guillaume F. Chanfreau, University of California, Los Angeles, CA, United States.
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| 250 |
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|a First edition.
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| 264 |
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1 |
|a Cambridge, MA :
|b Elsevier Ltd. :
|b Academic Press,
|c [2017]
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| 300 |
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|a 1 online resource (xi, 329 pages
|b illustrtions).
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Enzymes ;
|v v. 41
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| 546 |
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|a Text in English.
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| 504 |
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|a Includes bibliographical references.
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| 520 |
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|a RNA Modification, Volume 41, examines the powerful ability to regulate the function of RNA molecules or modify the message transmitted by RNA molecules. This field has recently seen a very rapid progress in our understanding of the mechanism and enzymes involved in RNA modification. This volume presents some of the most recent advances in the identification and function of enzymes involved in modifying RNA molecules.Features authoritative expertise from recognized contributors to the field. Presents the most recent advances in the rapidly evolving field of RNA modification.
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| 505 |
0 |
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|a Title page; Table of Contents; Copyright; Contributors; Preface; Chapter One: The Importance of Being Modified: The Role of RNA Modifications in Translational Fidelity; Abstract; 1 Introduction; 2 Human Mitochondrial tRNAMet Decodes the 1:3 Degenerate Codon Box; 3 tRNA Decoding of the Twofold, 2:2, Degenerate Codon Box; 4 tRNA Decoding of Codon Fourfold Degeneracy; 5 Three Amino Acids Are Encoded by Six Synonymous Codons Each; 6 Posttranscriptional Modification of tRNA Is Required for Accurate and Efficient Decoding; Acknowledgment
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|a Chapter Two: The Evolution of Substrate Specificity by tRNA Modification EnzymesAbstract; 1 Introduction; 2 The Problem of tRNA Recognition; 3 Deaminases That Target tRNA; 4 The Diversity of RNA Methylations, Methyltransferases, and Their Modes of tRNA Binding; 5 Sequence vs Structural Determinants for Specificity; 6 Preexisting Modifications and Their Requirement for Specificity; 7 Multisubunit Methyltransferases; 8 Pseudouridine Synthases; 9 Classification of RNA Pseudouridine Synthases and the Conserved Catalytic Core Domain; 10 RNA Binding: Contributions From Peripheral Domains
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|a 11 Multisubstrate Specificity of Pseudouridine Synthases12 Conclusion; Acknowledgments; Chapter Three: TrmD: A Methyl Transferase for tRNA Methylation With m1G37; Abstract; 1 Introduction; 2 Global Structure of TrmD; 3 The Trefoil Knot of TrmD and Mutations in the Knot; 4 Synthesis of m1G37-tRNA by TrmD; 5 Ribosome Frameshifting in the Absence of TrmD; 6 Mg2+ Dependence for Methyl Transfer; 7 Regulation of Mg2+ Transport in Salmonella; 8 Conclusion; Acknowledgments; Chapter Four: Structures and Activities of the Elongator Complex and Its Cofactors; Abstract
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| 505 |
8 |
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|a 1 Yeast Elongator: tRNA-Modifying Complex2 Elongator in Other Eukaryotes; 3 Proteins Required for Wobble Uridine Modification; 4 Concluding Remarks; Acknowledgments; Chapter Five: Posttranscriptional RNA Pseudouridylation; Abstract; 1 Introduction; 2 Mechanism of Pseudouridylation; 3 Structure of Box H/ACA RNP; 4 Three Elements Required for Box H/ACA RNP Activity; 5 Experimental Systems to Study Pseudouridylation; 6 Inducible Pseudouridylation; 7 mRNA Pseudouridylation; 8 Concluding Remarks; Acknowledgments
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| 505 |
8 |
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|a Chapter Six: Synthesis, Function, and Heterogeneity of snoRNA-Guided Posttranscriptional Nucleoside Modifications in Eukaryotic Ribosomal RNAsAbstract; 1 Introduction; 2 Inventory of rRNA Nucleoside Modifications and snoRNAs in Yeast and Mammals; 3 Structure of s(no)RNPs and Mode of Catalysis; 4 Role of rRNA Nucleoside Modifications in Ribosome Function; 5 Emergence of the Concept of Heterogeneous/Specialized Ribosomes; Chapter Seven: Adenosine Deaminases That Act on RNA (ADARs); Abstract; 1 Introduction; 2 Occurrence of Inosine in RNA; 3 Adenosine Deaminases That Act on RNA (ADARs)
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| 650 |
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0 |
|a RNA editing.
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| 650 |
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0 |
|a Nucleic acids
|x Metabolism.
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| 650 |
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0 |
|a Nucleosidases.
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| 650 |
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0 |
|a Enzymes.
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| 650 |
|
7 |
|a SCIENCE / Life Sciences / Biochemistry
|2 bisacsh
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| 650 |
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7 |
|a Enzymes.
|2 fast
|0 (OCoLC)fst00913605
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| 650 |
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7 |
|a Nucleic acids
|x Metabolism.
|2 fast
|0 (OCoLC)fst01041076
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| 650 |
|
7 |
|a Nucleosidases.
|2 fast
|0 (OCoLC)fst01041097
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| 650 |
|
7 |
|a RNA editing.
|2 fast
|0 (OCoLC)fst01086255
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| 655 |
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4 |
|a Electronic books.
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| 700 |
1 |
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|a Chanfreau, Guillaume F.,
|e editor.
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| 776 |
0 |
8 |
|c Original
|z 012811777X
|z 9780128117774
|w (OCoLC)964383649
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| 830 |
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0 |
|a Enzymes ;
|v v. 41.
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| 856 |
4 |
0 |
|u https://www.sciencedirect.com/science/bookseries/18746047/41
|z Full Text via HEAL-Link
|
