Erythropoietin /

• Άλλοι συγγραφείς: Litwack, Gerald (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cambridge, MA : Academic Press, is an imprint of Elsevier, 2017.
• Έκδοση: First edition.
• Σειρά: Vitamins and hormones ; v. 105.
• Θέματα: Erythropoietin.; MEDICAL / Physiology; SCIENCE / Life Sciences / Human Anatomy & Physiology; Electronic books.

Erythropoietin, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions a...

Πίνακας περιεχομένων:

• Title page; Table of Contents; Copyright; Former Editors; Contributors; Preface; Chapter One: Erythropoietin Receptor Structural Domains; Abstract; 1 Introduction; 2 Domain Architecture of the EpoR; 3 The Extracellular Domain of the EpoR; 4 TM Domain of the EpoR; 5 The C-Terminus of the EpoR; 6 Conclusion and Future Directions; Chapter Two: Analysis of the Asymmetry of Activated EPO Receptor Enables Designing Small Molecule Agonists; Abstract; 1 Introduction; 2 The Search for EPO Mimetics; 3 Comparing the Amgen and RWJ Work on EPO
• 4 Activation Requires Induced Asymmetry Not Specific Interactions5 Simulated Annealing of Chemical Potential; 6 Experimental Confirmation of the Theories and Computation Predictions; 7 Conclusions; 8 Acknowledgments; Chapter Three: Endogenous Erythropoietin; Abstract; 1 Introduction; 2 What Is Endogenous Human EPO, What Does It Do, and How Do We Know?; 3 Summary and Conclusion; Acknowledgments; Chapter Four: Erythropoietin Regulation by Angiotensin II; Abstract; 1 Introduction; 2 RAS in the Regulation of Blood Cell Homeostasis In Vivo; 3 RAS Regulation of Erythropoietin In Vivo
• 4 Molecular Mechanisms of ANG II Regulation of EPO Expression5 Biphasic Effects of ACE Inhibitors on Radiation-Induced Hematopoietic Injury; 6 Summary and Conclusions; Acknowledgments; Chapter Five: Erythropoietin Receptor Signaling and Lipid Rafts; Abstract; 1 Introduction; 2 Epo and Epo Receptor; 3 Conditions With Aberrant Epo Signaling; 4 Epo Receptor Signaling; 5 Lipid Rafts; 6 Lipid Rafts and Epo Signaling; 7 Clinical Implications; 8 Conclusion and Future Directions; Chapter Six: Erythropoietin and Hypothalamic-Pituitary Axis; Abstract; 1 Erythropoietin
• 2 Erythropoietin and Brain Development3 Effects of Erythropoietin Receptor Gene Knockout in Metabolism; 4 Effects of Erythropoietin Treatment and Overexpression in Metabolism; 5 The Hypothalamic-Pituitary Axis; 6 Hypothalamus; 7 Hypothalamus and Pituitary Gland Cross Talk; 8 Posttranslational Processing of POMC: ACTH Synthesis and Release; 9 Erythropoietin Effects in Hypothalamus and Pituitary; 10 Conclusions; Chapter Seven: Erythropoietin-Mediated Regulation of Central Respiratory Command; Abstract; 1 Erythropoietin; 2 Control of the Respiratory System
• 3 Peripheral Epo Regulation of Respiratory Parameters4 Epo Regulation on the Central Respiratory Command; 5 Factors Influencing Epo-Mediated Regulation of the Respiratory Command; 6 Conclusion; Acknowledgment; Chapter Eight: Mutual Cross Talk Between Iron Homeostasis and Erythropoiesis; Abstract; 1 Introduction; 2 Systemic Iron Homeostasis; 3 Regulation of Hepcidin Expression; 4 Conclusion and Future Directions; Acknowledgment; Chapter Nine: Context-Dependent Skeletal Effects of Erythropoietin; Abstract; 1 Introduction; 2 In Vitro Effects of Epo; 3 Regulation of Bone Homeostasis by Epo