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04490nam a2200493 4500 |
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ocn994430144 |
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OCoLC |
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20180501122036.0 |
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m o d |
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cr |n||||||||| |
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170724s2017 enka ob 000 0 eng d |
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|a YDX
|b eng
|c YDX
|d N$T
|d IDEBK
|d OPELS
|d EBLCP
|d N$T
|d OCLCQ
|d OCLCF
|e rda
|d MEU
|d GrThAP
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| 019 |
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|a 994205720
|a 994917577
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| 020 |
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|a 9780128498637
|q (electronic bk.)
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|a 0128498633
|q (electronic bk.)
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|a 9780128118702
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|a 0128118709
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| 035 |
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|a (OCoLC)994430144
|z (OCoLC)994205720
|z (OCoLC)994917577
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| 050 |
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4 |
|a QP623.5.S63
|b .M56 2017eb
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| 072 |
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7 |
|a SCI
|x 007000
|2 bisacsh
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| 082 |
0 |
4 |
|a 572.8/8
|2 23
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| 049 |
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|a TEFA
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| 245 |
0 |
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|a MiRNAs in Differentiation and Development /
|c edited by Lorenzo Galluzzi and Ilio Vitale.
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| 264 |
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1 |
|a London :
|b Academic Press,
|c 2017.
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| 300 |
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|a 1 online resource (x, 323 pages :
|b illustrations (some color)).
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 546 |
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|a Text in English.
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| 504 |
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|a Includes bibliographical references.
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0 |
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|a Print version record.
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|a Front Cover; MiRNAs in Differentiation and Development; Copyright; Contents; Contributors; Chapter One: MicroRNAs in DNA Damage Response, Carcinogenesis, and Chemoresistance; 1. Introduction; 2. MiRNA Regulation in Response to DNA Damage; 2.1. Transcriptional Regulation of MiRNAs; 2.2. Posttranscriptional Regulation of MiRNAs; 3. DNA Damage Response Regulation by MiRNAs; 3.1. Sensors of DNA Damage and Mediators of the DNA Damage Response; 3.2. Transducers of the DNA Damage Response; 3.3. Effectors of the DNA Damage Response; 3.3.1. Effectors of Apoptosis; 3.3.2. Effectors of the Cell Cycle
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| 505 |
8 |
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|a 3.3.3. Effectors of DNA Repair4. MiRNAs in Cancer; 4.1. MiRNAs as Oncogenes; 4.2. MiRNAs as Tumor Suppressors; 4.3. MiRNAs as Both Oncogenes and Tumor Suppressor Genes; 5. The Role of MiRNAs in Drug Resistance; 5.1. MiRNAs Regulate Drug Resistance Through Survival and/or Apoptosis Pathways; 5.2. MiRNAs Regulate Drug Resistance Through the Drug-Targeting and DNA-Repair Pathways; 5.3. MiRNAs Regulate Drug Resistance Through Regulating Drug Delivery and Drug Metabolism; 5.4. MiRNAs Regulate Drug Resistance in Pharmacogenomics; 6. Conclusion; References
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| 505 |
8 |
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|a Chapter Two: MicroRNAs as Key Effectors in the p53 Network1. Introduction; 2. MicroRNAs, Small Helpers With Big Effects in the p53 Pathway; 2.1. p53 Transcriptionally Upregulates MicroRNAs; 2.2. p53 Transcriptionally Downregulates a Subset of MicroRNAs; 2.3. p53 Modulates MicroRNA Maturation and mRNA Accessibility; 2.4. p53 Is a Direct Target of MicroRNAs; 2.5. p53 Is an Indirect Target of MicroRNAs; 3. MicroRNAs Engaged in Fulfilling GOF Activities of Mutant p53; 3.1. MicroRNAs Transcriptionally Regulated by Mutant p53
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|a 3.2. Mutant p53 Regulates MicroRNA Biogenesis at Posttranscriptional Level4. Conclusions; Acknowledgments; References; Chapter Three: Impact of MicroRNAs in the Cellular Response to Hypoxia; 1. Introduction; 2. Regulation of MiRNA Expression by Hypoxia; 2.1. Control of hypoxamiRs Expression Through HIFs-Dependent Mechanisms; 2.1.1. MiR-210; 2.1.2. Other hypoxamiRs; 2.2. HIF-Independent Transcriptional Regulation of hypoxamiRs; 2.3. Epigenetic Mechanisms; 2.4. Regulation of MiRNA Biogenesis by Hypoxia; 2.5. MiRNA Export and Hypoxia
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|a 3. The Diverse Roles of MiRNAs in Cellular Adaptation to Hypoxia3.1. The hypoxamiR Targetome: Present and Future; 3.2. Feedback Regulatory Loops Between MiRNAs and Hypoxia; 3.2.1. MiR-210; 3.2.2. Other hypoxamiRs; 3.3. Metabolic Adaptation; 3.3.1. MiR-210; 3.3.2. Other hypoxamiRs; 3.4. Cell Cycle; 3.4.1. MiR-210; 3.4.2. Other hypoxamiRs; 3.5. DNA Repair; 3.5.1. MiR-210; 3.5.2. Other hypoxamiRs; 3.6. Apoptosis; 3.6.1. MiR-210; 3.6.2. Other hypoxamiRs; 3.7. Angiogenesis; 3.7.1. MiR-210; 3.7.2. Other hypoxamiRs; 3.8. Inflammation and Immunity; 3.8.1. MiR-210; 3.8.2. Other hypoxamiRs
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| 650 |
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0 |
|a MicroRNA.
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| 650 |
|
7 |
|a SCIENCE / Life Sciences / Biochemistry
|2 bisacsh
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| 650 |
|
7 |
|a MicroRNA.
|2 fast
|0 (OCoLC)fst01940234
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| 655 |
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4 |
|a Electronic books.
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| 700 |
1 |
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|a Galluzzi, Lorenzo,
|e editor.
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| 700 |
1 |
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|a Vitale, Ilio,
|e editor.
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| 830 |
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0 |
|a International review of cell and molecular biology ;
|v v. 333.
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| 856 |
4 |
0 |
|u https://www.sciencedirect.com/science/bookseries/19376448/333
|z Full Text via HEAL-Link
|
