MiRNAs in Differentiation and Development /

• Άλλοι συγγραφείς: Galluzzi, Lorenzo (Επιμελητής έκδοσης), Vitale, Ilio (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: London : Academic Press, 2017.
• Σειρά: International review of cell and molecular biology ; v. 333.
• Θέματα: MicroRNA.; SCIENCE / Life Sciences / Biochemistry; Electronic books.

Πίνακας περιεχομένων:

• Front Cover; MiRNAs in Differentiation and Development; Copyright; Contents; Contributors; Chapter One: MicroRNAs in DNA Damage Response, Carcinogenesis, and Chemoresistance; 1. Introduction; 2. MiRNA Regulation in Response to DNA Damage; 2.1. Transcriptional Regulation of MiRNAs; 2.2. Posttranscriptional Regulation of MiRNAs; 3. DNA Damage Response Regulation by MiRNAs; 3.1. Sensors of DNA Damage and Mediators of the DNA Damage Response; 3.2. Transducers of the DNA Damage Response; 3.3. Effectors of the DNA Damage Response; 3.3.1. Effectors of Apoptosis; 3.3.2. Effectors of the Cell Cycle
• 3.3.3. Effectors of DNA Repair4. MiRNAs in Cancer; 4.1. MiRNAs as Oncogenes; 4.2. MiRNAs as Tumor Suppressors; 4.3. MiRNAs as Both Oncogenes and Tumor Suppressor Genes; 5. The Role of MiRNAs in Drug Resistance; 5.1. MiRNAs Regulate Drug Resistance Through Survival and/or Apoptosis Pathways; 5.2. MiRNAs Regulate Drug Resistance Through the Drug-Targeting and DNA-Repair Pathways; 5.3. MiRNAs Regulate Drug Resistance Through Regulating Drug Delivery and Drug Metabolism; 5.4. MiRNAs Regulate Drug Resistance in Pharmacogenomics; 6. Conclusion; References
• Chapter Two: MicroRNAs as Key Effectors in the p53 Network1. Introduction; 2. MicroRNAs, Small Helpers With Big Effects in the p53 Pathway; 2.1. p53 Transcriptionally Upregulates MicroRNAs; 2.2. p53 Transcriptionally Downregulates a Subset of MicroRNAs; 2.3. p53 Modulates MicroRNA Maturation and mRNA Accessibility; 2.4. p53 Is a Direct Target of MicroRNAs; 2.5. p53 Is an Indirect Target of MicroRNAs; 3. MicroRNAs Engaged in Fulfilling GOF Activities of Mutant p53; 3.1. MicroRNAs Transcriptionally Regulated by Mutant p53
• 3.2. Mutant p53 Regulates MicroRNA Biogenesis at Posttranscriptional Level4. Conclusions; Acknowledgments; References; Chapter Three: Impact of MicroRNAs in the Cellular Response to Hypoxia; 1. Introduction; 2. Regulation of MiRNA Expression by Hypoxia; 2.1. Control of hypoxamiRs Expression Through HIFs-Dependent Mechanisms; 2.1.1. MiR-210; 2.1.2. Other hypoxamiRs; 2.2. HIF-Independent Transcriptional Regulation of hypoxamiRs; 2.3. Epigenetic Mechanisms; 2.4. Regulation of MiRNA Biogenesis by Hypoxia; 2.5. MiRNA Export and Hypoxia
• 3. The Diverse Roles of MiRNAs in Cellular Adaptation to Hypoxia3.1. The hypoxamiR Targetome: Present and Future; 3.2. Feedback Regulatory Loops Between MiRNAs and Hypoxia; 3.2.1. MiR-210; 3.2.2. Other hypoxamiRs; 3.3. Metabolic Adaptation; 3.3.1. MiR-210; 3.3.2. Other hypoxamiRs; 3.4. Cell Cycle; 3.4.1. MiR-210; 3.4.2. Other hypoxamiRs; 3.5. DNA Repair; 3.5.1. MiR-210; 3.5.2. Other hypoxamiRs; 3.6. Apoptosis; 3.6.1. MiR-210; 3.6.2. Other hypoxamiRs; 3.7. Angiogenesis; 3.7.1. MiR-210; 3.7.2. Other hypoxamiRs; 3.8. Inflammation and Immunity; 3.8.1. MiR-210; 3.8.2. Other hypoxamiRs