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05306nam a2200625 4500 |
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on1002006090 |
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OCoLC |
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20180501122037.0 |
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m o d |
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cr |n||||||||| |
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170825s2017 maua ob 001 0 eng d |
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|a YDX
|b eng
|c YDX
|d N$T
|d IDEBK
|d NLE
|d EBLCP
|d N$T
|d OPELS
|d OCLCF
|d UPM
|d OHS
|d OCLCO
|d SNM
|e rda
|d MEU
|d OCLCO
|d D6H
|d GrThAP
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|a 1001809122
|a 1002115248
|a 1029442351
|a 1029489121
|a 1031318662
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|a 9780128112274
|q (electronic bk.)
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|a 0128112271
|q (electronic bk.)
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|a 9780128112267
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|a 0128112263
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|a (OCoLC)1002006090
|z (OCoLC)1001809122
|z (OCoLC)1002115248
|z (OCoLC)1029442351
|z (OCoLC)1029489121
|z (OCoLC)1031318662
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| 050 |
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4 |
|a QR502
|b .P749 2017eb
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| 072 |
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7 |
|a SCI
|x 008000
|2 bisacsh
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| 072 |
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|a SCI
|x 045000
|2 bisacsh
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| 082 |
0 |
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|a 579.29
|2 23
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| 049 |
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|a TEFA
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| 245 |
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|a Prion Protein /
|c edited by Giuseppe Legname, Silvia Vanni.
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| 250 |
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|a First edition.
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| 264 |
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1 |
|a Cambridge, MA :
|b Academic Press,
|c 2017.
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| 300 |
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|a 1 online resource (xix, 495 pages :
|b illustrations).
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Progress in molecular biology and translational science ;
|v volume 150
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| 546 |
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|a Text in English.
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| 504 |
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|a Includes bibliographical references and index..
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|a Front Cover; Prion Protein; Copyright; Contents; Contributors; Preface; Chapter One: Functions of the Prion Protein; 1. Introduction; 2. The Basics of PrPC; 2.1. PrPC From Gene to Function; 2.2. PrPC Expression and Localization; 3. Lessons From Knockout Models; 4. Miscellaneous Roles in CNS Function; 4.1. Cognitive and Behavioral Functions; 4.2. Neuritogenesis and Neuronal Differentiation; 4.3. Balancing Neuroprotection and Neurotoxicity; 4.4. Beyond Neurons: PrPC in Glia; 4.5. The Metal Connection; 4.6. From Neurotransmitter Receptors to Neurotransmitter-Associated Functions
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| 505 |
8 |
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|a 5. Cell Fate and Differentiation5.1. Stem Cell Self-renewal and Expansion; 5.2. A Hub in Developmental Signaling Pathways; 5.3. Choice of Cell Fate and Differentiation; 6. A Broad Protective Role Against Stress; 6.1. PrPC Is Induced Under Stress; 6.2. Protection Against Oxidative Stress; 6.3. Protection Against Genotoxic Stress; 6.4. Protection Against Apoptosis; 6.5. An Immune Privilege Molecule?; 6.6. Involvement in Proteostasis; 7. Cell Adhesion and ECM Contacts; 7.1. Multiple Adhesion Partners; 7.2. Special Links With Cadherins; 7.3. Modulating the ECM Composition
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|a 8. From Partners to Cell Signaling8.1. Cell Signaling: The Unifying Function of PrPC?; 8.2. A Great Variety of Partners; 8.3. Overview of PrPC-Dependent Signal Transduction; 9. Concluding Remarks; References; Chapter Two: Copper- and Zinc-Promoted Interdomain Structure in the Prion Protein: A Mechanism for Autoinhibition of the ...; 1. Introduction; 1.1. PrPC Structure; 1.2. Molecular Features of Cu2+ and Zn2+ Binding; 1.3. Metal Ions and PrPC Function; 2. The N-Terminal Toxicity Hypothesis; 2.1. Internal Deletions of PrPC; 2.2. N-Terminal Toxicity Induced by GD Ligands
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| 505 |
8 |
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|a 3. Cu2+ and Zn2+ Promote Interdomain Interaction in cis4. Disruption of cis Interaction as a Mechanism of Neurotoxicity; 5. Concluding Remarks; Acknowledgment; References; Chapter Three: Cell Biology of Prion Protein; 1. Expression and Function of Prion Protein; 2. PrPC: The Principal Actor in Prion Replication; 3. Structure and Biosynthesis of PrPC; 4. Trafficking of Cellular Prion Protein; 5. Several Topological Forms of PrPC; 6. Quality Control of Cellular Prion Protein; 7. GPI-Anchor: Structure and Biosynthesis; 8. Functions of GPI-Anchored Proteins; 9. GPI-Anchor Function
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| 505 |
8 |
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|a 10. GPI-Anchor and PrionReferences; Chapter Four: Understanding the Effect of Disease-Related Mutations on Human Prion Protein Structure: Insights From NMR S ...; 1. Introduction; 2. Structural Features of PrPC and PrPSc; 3. Strategy for Resonance Assignment and NMR Structure Determination of Human Prion Protein Variants; 4. Structural Features of Human Prion Proteins With Pathological Mutations; 4.1. Mildly Acidic pH Conditions; 4.2. Physiological pH Conditions; 5. Structural Features of Human Prion Protein With Protective E219K Polymorphism; 6. Concluding Remarks; Acknowledgment; References
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| 650 |
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0 |
|a Prions.
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| 650 |
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0 |
|a Prion diseases.
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| 650 |
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0 |
|a Nervous system
|x Degeneration.
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| 650 |
|
7 |
|a SCIENCE / Life Sciences / Biology.
|2 bisacsh
|
| 650 |
|
7 |
|a SCIENCE / Life Sciences / Microbiology.
|2 bisacsh
|
| 650 |
|
7 |
|a Nervous system
|x Degeneration.
|2 fast
|0 (OCoLC)fst01036090
|
| 650 |
|
7 |
|a Prion diseases.
|2 fast
|0 (OCoLC)fst01076975
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| 650 |
|
7 |
|a Prions.
|2 fast
|0 (OCoLC)fst01076986
|
| 650 |
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2 |
|a Prions.
|0 (DNLM)D011328
|
| 650 |
|
2 |
|a Prion Diseases.
|0 (DNLM)D017096
|
| 650 |
|
2 |
|a Nervous System Diseases.
|0 (DNLM)D009422
|
| 655 |
|
4 |
|a Electronic books.
|
| 700 |
1 |
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|a Legname, Giuseppe,
|e editor.
|
| 700 |
1 |
|
|a Vanni, Silvia,
|e editor.
|
| 776 |
0 |
8 |
|c Original
|z 9780128112267
|z 0128112263
|w (OCoLC)974699161
|
| 830 |
|
0 |
|a Progress in molecular biology and translational science ;
|v v. 150.
|
| 856 |
4 |
0 |
|u https://www.sciencedirect.com/science/bookseries/18771173/150
|z Full Text via HEAL-Link
|
