miRNA and Cancer /

• Άλλοι συγγραφείς: Croce, Carlo (Επιμελητής έκδοσης), Fisher, Paul B. (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cambridge, MA : Academic Press, is imprint of Elsevier, [2017].
• Έκδοση: First edition.
• Σειρά: Advances in cancer research ; v. 135.
• Θέματα: Cancer > Genetic aspects.; Cancer genes.; HEALTH & FITNESS / Diseases / General.; MEDICAL / Clinical Medicine.; MEDICAL / Diseases.; MEDICAL / Evidence-Based Medicine.; MEDICAL / Internal Medicine.; Neoplasms > genetics.; Electronic books.

Πίνακας περιεχομένων:

• 6.4. MDA-7/IL-246.5. hPNPase; 6.6. hnRNPA1; 6.7. ADARs; 6.8. Stress; 6.9. Diet and Natural Products; 7. Conclusions and Future Perspectives; Acknowledgments; References; Chapter Three: Animal Models to Study MicroRNA Function; 1. Introduction; 1.1. MicroRNA Biogenesis, Mechanism of Action and Function; 1.1.1. Biogenesis; 1.1.1.1. Expression of MiRNA Genes; 1.1.1.1.1. Regulation Mediated by Availability of Transcription Factors; 1.1.1.1.2. Regulation Mediated by Genomic Location of MiRNA Genes; 1.1.1.1.2.1. Location in the Epigenome; 1.1.1.1.2.2. Location Relative to Host Genes
• 1.1.1.1.2.3. Regulation by MiRNA Copy Number1.1.1.1.2.4. Cancer-Associated Genomic Regions; 1.1.1.2. Process of Biogenesis; 1.1.2. Mechanisms of Action and Functions of MiRNAs; 1.1.2.1. Incorporation Into miRISC and Targeting; 1.1.2.2. The Role of Family Members in Expression and Targeting; 1.1.2.3. The Role of MiRNA Clusters and Paralogous in Targeting; 1.1.2.4. Use of Bioinformatics to Elucidate MiRNA Function; 1.2. MiRNA Function and Relevance in Cancer; 1.2.1. OncomiRs; 1.2.2. Tumor-Suppressive MiRNA; 1.3. Tools That Advanced MiRNA Research
• 2. Generation of Model Organisms and Their Use in MiRNA Functional Studies2.1. Caenorhabditis elegans; 2.1.1. Generation of Transgenic C. elegans for Use in MiRNA Functional Studies; 2.1.2. C. elegans as a Model System for Studying the Function of MiRNAs in Cancer; 2.2. Drosophila melanogaster (Fruit Flies); 2.2.1. Generation of Transgenic D. melanogaster to Model Cancer Phenotypes; 2.2.2. D. melanogaster as a Model for Studying the Functions of MiRNAs in Cancer; 2.3. Danio rerio (Zebrafish); 2.3.1. Generation of Transgenic D. rerio for Use in MiRNA Functional Research
• 2.3.2. D. rerio as a Model for Studying the Function of MiRNA in Cancer2.4. Mus musculus (Mouse); 2.4.1. Generation of Transgenic M. musculus for Use in MiRNA Functional Research; 2.4.1.1. Genetically Engineered Mouse Models Generated via Transgenesis; 2.4.1.2. GEMMs Generated via Homologous Recombination; 2.4.2. Strategies Utilized to Generate Gene-Targeting Vectors; 2.4.2.1. Cre-LoxP System; 2.4.2.2. Flp-FRT System; 2.4.2.3. Inducible Systems; 2.4.2.3.1. Tetracycline ON/OFF System; 2.4.2.3.2. Cre-ER(T) System; 2.4.3. Using M. musculus for MiRNA Functional Studies in Cancer; 3. Conclusion