Current topics in membranes : sterol regulation of ion channels /

• Άλλοι συγγραφείς: Levitan, Irena (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cambridge, Massachusetts ; London, England : Academic Press, 2017.
• Σειρά: Current topics in membranes ; v. 80.
• Θέματα: Ion channels.; Sterols.; SCIENCE / Life Sciences / Anatomy & Physiology.; Electronic books.

Πίνακας περιεχομένων:

• Front Cover; Sterol Regulation of Ion Channels; Copyright; Contents; Contributors; Preface; Acknowledgments; Section 1: Membrane Structure and General Mechanisms of Sterol Regulation of Ion Channels; Chapter One: Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other ...; 1. Introduction; 2. Experimental Validation of the CARC Motif; 3. Coexistence of CARC and CRAC Sequences Within the Same TM Domain; 4. Reliability of the CARC and CRAC Algorithms; 5. Cholesterol and Its Key Role in Liquid-Ordered Lipid Domains
• 6. Evolutionary Conservation of Sterol-Recognition MotifsAcknowledgments; References; Chapter Two: Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response; 1. Introduction; 2. Physical Properties of Membrane Bilayer: Sterol Analysis; 2.1. 3D Sterol Structure of Cholesterol Chiral Analogues; 2.2. Position Within the Bilayer; 2.3. Lipid Order and Packing; 3. Differential Effects of Sterols on the Ion Channel Function: Prevalence of Stereospecific Effects; 3.1. Stereospecific Effects of Cholesterol on Ion Channels
• 3.1.1. Inwardly Rectifying K+ (Kir) Channels3.1.2. Large-Conductance Ca2+-Sensitive Voltage-Gated K+ Channels (BK); 3.1.3. Transient Receptor Potential Vanilloid 1 (TRPV1) Channels; 3.1.4. GABAA Receptors; 3.2. Nonstereospecific Effects of Cholesterol on Ion Channels; 3.2.1. Nicotinic Acetylcholine Receptor (nAChR); 3.2.2. Volume-Regulated Anion Channels (VRACs); 4. Evidence for Direct Binding and Sterol Competition for the Binding Sites: Kir Channels; 4.1. Challenges of the Approach; 4.2. Cholesterol Binding to KirBac1.1 Channels Is Not Stereospecific
• 5. Computational Analysis of the Stereospecificity of Cholesterol Binding to Ion Channels6. Conclusions and Future Directions; Acknowledgments; References; Section 2: Structural Determinants of Cholesterol-Ion Channels Interactions; Chapter Three: Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites; 1. Biology and Chemistry of Cholesterol and Bile Acids; 1.1. Cholesterol in Physiology and Disease; 1.2. Bile Acids in Physiology and Disease; 1.3. Connections in the Chemistry and Metabolism of Cholesterol and Bile Acids
• 1.4. Evidence for Direct Interactions Between Cholesterol and Ion Channel Proteins1.5. Evidence for Direct Interactions Between Bile Acids and Ion Channel Proteins; 2. Modulation of BK Channels by Cholesterol or Bile Acids; 2.1. Voltage- and Ca2+-Gated, Large Conductance K+ (BK) Channels; 2.2. Cholesterol and BK Channel-Mediated Currents; 2.3. Mechanisms Underlying Cholesterol Modulation of BK Channel Activity; 2.3.1. Mechanisms Driven by Changes in the Physicochemical Properties of the Lipid Bilayer; 2.3.2. Direct Cholesterol-BK Protein Interactions