Natural variation and clocks /

• Άλλοι συγγραφείς: Goodwin, Stephen F. (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cambridge, MA : Academic Press, 2017.
• Έκδοση: First edition.
• Σειρά: Advances in genetics ; v. 99.
• Θέματα: Genetics > Research.; Circadian rhythms.; Variation (Biology); Biological rhythms.; Medical genetics.; Neurosciences.; SCIENCE / Life Sciences / Evolution.; Circadian Rhythm.; Genetics, Medical.; Electronic books.

Natural Variances and Clocks provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs and advances. This updated release includes chapters on a variety of new research, including the Natural variation of the circadian clock in Neurospora, Natura...

Πίνακας περιεχομένων:

• ""Front Cover""; ""Natural Variation and Clocks""; ""Copyright""; ""Contents""; ""Contributors""; ""Preface""; ""Chapter One: Natural Variation of the Circadian Clock in Neurospora""; ""1. Introduction""; ""2. Neurospora in Nature""; ""2.1. The Genus of Neurospora""; ""2.2. Natural Habitats""; ""2.3. Collection of Neurospora Ecotypes""; ""2.4. Neurospora as a Model for Clock Variation Studies""; ""3. The Circadian Clock of Neurospora""; ""3.1. FRQ-Dependent Oscillators""; ""3.1.1. Simple and Coupled Loops""; ""3.1.1.1. Positive Regulation of WC-1""; ""3.1.1.2. Coupled Loops in WCC""
• ""3.1.1.3. Negative Regulation of FRQ""""3.1.2. Interlocked Loops in WCC/FRQ""; ""3.1.2.1. Negative Feedback Loop""; ""3.1.2.2. Positive Feedback Loop""; ""3.1.3. Posttranslational Modification of WCC and FFC""; ""3.1.4. Negative Feedback Loop in WCC/FRQ/VVD""; ""3.2. FRQ-Independent Oscillators""; ""4. Natural Variation and the Circadian Clock""; ""4.1. Natural Variation in Neurospora Ecotypes""; ""4.2. Natural Variation of Core Clock Genes""; ""4.3. Technical Challenges for Studying Clock Variation in Neurospora Natural Populations""; ""4.4. Methods for Clock Variation Studies""
• ""4.4.1. QTL Analysis on Clock Phenotypes""""4.4.2. Circadian Clocks in Natural Substrates and Natural Environment""; ""5. Future Challenges""; ""6. Concluding Remarks""; ""Acknowledgments""; ""References""; ""Chapter Two: Natural Variation and Genetics of Photoperiodism in Wyeomyia smithii""; ""1. Introduction""; ""1.1. Raison dâ#x80;#x99;ître of Photoperiodism""; ""1.2. Geographic Clines""; ""1.3. Photoperiodism in Wyeomyia smithii""; ""1.3.1. Photoperiodism and Phylogeography""; ""1.3.2. Geography of Photoperiodic Response""; ""2. Genetics of Photoperiodic Response""
• ""2.1. Genetic Potential to Respond to Selection""""2.2. Hidden Genetic Variation""; ""2.2.1. Genotype by Environment Interaction""; ""2.2.2. Dominance and Epistasis""; ""2.3. Mapping Genotype to Phenotype""; ""2.4. Lessons From Quantitative Genetic Approaches in Wyeomyia smithii""; ""3. Photoperiodism and Climate Change""; ""4. Photoperiodism and Circadian Rhythmicity""; ""4.1. Functionality, Definitions, and the Evolutionary Perspective""; ""4.2. Daily vs Seasonal Timing""; ""4.2.1. BÃơnningâ#x80;#x99;s Proposition Then and Subsequently""; ""4.2.2. How W. smithii Assesses Day Length""
• ""4.2.3. Resonance""""4.3. Molecular Connections and Pleiotropy""; ""5. Conclusions""; ""Acknowledgments""; ""References""; ""Chapter Three: Natural Variation in Human Clocks""; ""1. Introduction""; ""2. Direct Measurement of Human Period""; ""3. Proxies of Human Period""; ""4. Extremes of Human Circadian Period""; ""5. Genetic Control of Circadian Rhythms in Mammals""; ""6. Genetic Studies of Circadian Rhythm Sleep Disorders""; ""7. Genetic Associations With Measured Behavioral Rhythms""; ""8. Single-Gene Association Studies of Questionnaire-Determined Human Chronotype""