Peptidomics of Cancer-Derived Enzyme Products /
| Other Authors: | , |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Cambridge, MA :
Academic Press,
[2017].
|
| Edition: | First edition. |
| Series: | Enzymes ;
v. 42. |
| Subjects: | |
| Online Access: | Full Text via HEAL-Link |
Table of Contents:
- ""Front Cover""; ""Peptidomics of Cancer-Derived Enzyme Products""; ""Copyright""; ""Contents""; ""Contributors""; ""Preface""; ""Overview""; ""1. Molecular Changes in Cancer""; ""2. Peptidomes and Advance in Mass Spectrometry""; ""3. Nanotechnology and Nanodevices""; ""4. Future Perspective""; ""Chapter One: Circulating Peptidome and Tumor-Resident Proteolysis""; ""1. Introduction""; ""1.1. Intracellular Proteases""; ""1.1.1. Caspases (Cysteine Protease)""; ""1.1.2. Deubiquitinases (Cysteine and Zinc Proteases)""; ""1.1.3. Autophagins (Cysteine Proteases)""; ""1.2. Extracellular Proteases""
- ""1.2.1. Matrix Metalloproteinases""""1.2.2. Cysteine Cathepsins""; ""1.2.3. Kallikreins""; ""2. Organism and Cancer Degradomes""; ""3. Tumor-Associated Peptidomics""; ""4. Tumor Proteases Relative Peptide in Cancer Detection""; ""5. Conclusion""; ""References""; ""Chapter Two: The Peptidome Comes of Age: Mass Spectrometry-Based Characterization of the Circulating Cancer Peptidome""; ""1. Introduction""; ""2. Biological Role of Peptides""; ""3. Peptidomics: The Study of Physiological Peptides""; ""4. Mass Spectrometry and Top/Middle-Down Proteomics""
- ""4.1. Mass Spectrometry Technology Developments for Peptidomics""""4.2. Top-Top-Down or Native Mass Spectrometry""; ""4.3. Top-Down-Based Mass Spectrometric Imaging""; ""5. Strategies to Enrich the Peptidome""; ""5.1. Selective Precipitation""; ""5.2. Centrifugal Ultrafiltration""; ""5.3. Capillary Ultrafiltration""; ""5.4. Surface-Derivatised Magnetic Beads""; ""5.5. Nanoporous Substrates""; ""6. Application of Peptidomics in Cancer Biomarker Discovery""; ""6.1. Role of Peptidomics as in Cancer Biomarker Discovery""; ""6.2. Peptidomics and Cancer Diagnosis""
- ""6.3. Plasma Protein/Peptide Profiling""""6.4. The Plasma Interactome""; ""6.5. Endoproteolytic Cleavage""; ""6.6. Exoproteolytic Cleavage""; ""7. Data Processing and Informatics for Peptidome Analyses""; ""7.1. Sequence Databases""; ""7.2. Data Analyses""; ""7.3. Data Repository""; ""8. Emerging Technologies""; ""9. Future Perspectives""; ""Acknowledgments""; ""References""; ""Chapter Three: Peptide Hormones as Tumor Markers in Clinical Practice""; ""1. Introduction""; ""2. Selected Peptide Hormones as Tumor Markers""; ""2.1. Calcitonin""; ""2.1.1. Biosynthesis From Prohormone""
- ""2.1.2. Clinical Significance as Tumor Marker""""2.2. Alpha- and Beta-hCG""; ""2.2.1. Processing of hCG""; ""2.2.2. Clinical Applications as Tumor Markers""; ""2.3. Insulin and C-Peptide""; ""2.3.1. Biosynthesis From Prohormone""; ""2.3.2. Clinical Significance as Tumor Marker""; ""2.4. PTHrp""; ""2.4.1. Biosynthesis From Prohormone""; ""2.4.2. Clinical Significance as Tumor Marker""; ""2.5. Gastrin""; ""2.5.1. Biosynthesis From Prohormone""; ""2.5.2. Clinical Significance as Tumor Marker""; ""2.6. VIP""; ""2.6.1. Biosynthesis From Prohormone""
