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05114nam a2200541 4500 |
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on1031999496 |
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OCoLC |
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20200326101152.0 |
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m o d |
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cr cnu---unuuu |
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180423s2018 mau ob 000 0 eng d |
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|a N$T
|b eng
|e rda
|e pn
|c N$T
|d N$T
|d OPELS
|d EBLCP
|d YDX
|d OCLCQ
|d UPM
|d OCLCF
|d NLE
|d SOI
|d BRX
|d AU@
|d UKAHL
|d OCLCQ
|d GrThAP
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| 019 |
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|a 1032352279
|a 1032589799
|a 1032658726
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|a 9780128145753
|q (electronic bk.)
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|a 0128145757
|q (electronic bk.)
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|a 9780128145746
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|a 0128145749
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| 035 |
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|a (OCoLC)1031999496
|z (OCoLC)1032352279
|z (OCoLC)1032589799
|z (OCoLC)1032658726
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4 |
|a RD85.5
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| 072 |
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|a MED
|x 085000
|2 bisacsh
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|a 617.9/67
|2 23
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|a Chemical and biochemical approaches for the study of anesthetic function.
|p Part B /
|c edited by Roderic G. Eckenhoff, Ivan J. Dmochowski.
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| 250 |
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|a First edition.
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| 264 |
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1 |
|a Cambridge, MA :
|b Academic Press, an imprint of Elsevier,
|c 2018.
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| 300 |
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|a 1 online resource
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 347 |
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|a data file
|2 rda
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| 490 |
1 |
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|a Methods in enzymology ;
|v volume 603
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| 588 |
0 |
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|a Online resource; title from PDF title page (EBSCO, viewed April 24, 2018).
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|a Includes bibliographical references.
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|a Intro; Title page; Table of Contents; Copyright; Contributors; Preface; Section I: Structural Approaches; Chapter One: Structural Analysis of Anesthetics in Complex with Soluble Proteins; Abstract; 1 Introduction; 2 Crystallographic Issues Relevant to Analysis of Anesthetic Binding; 3 Crystallizing Apoferritin with Isoflurane and Propofol; 4 Protocol; 5 Analysis of the Structure; 6 Summary; Acknowledgment; Chapter Two: X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels; Abstract; 1 Introduction.
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| 505 |
8 |
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|a 2 Production of Monodisperse pLGICs with High Purity3 Crystallization of pLGICs in the Absence and Presence of General Anesthetics; 4 Functional Validation of the Bound Anesthetics; 5 Case Studies; Acknowledgments; Chapter Three: Solution NMR Studies of Anesthetic Interactions with Ion Channels; Abstract; 1 Introduction; 2 Preparation of Ion Channels for Solution NMR; 3 NMR Methods to Identify Anesthetics Binding Sites and Detect Anesthetic-Induced Dynamics Changes; 4 Case Studies; Acknowledgments.
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|a Chapter Four: Time-Resolved Neutron Interferometry and the Mechanism of Electromechanical Coupling in Voltage-Gated Ion ChannelsAbstract; 1 Introduction; 2 Methods; 3 Results; 4 Discussion; 5 Conclusions and Future Prospects; Acknowledgments; Section II: Evolving Biophysical Technologies; Chapter Five: Fluorescent Anesthetics; Abstract; 1 Introduction; 2 Value of 1-AMA for Studying General Anesthetic Mechanisms; 3 Value of 1-AZA for Studying General Anesthetic Mechanisms; 4 Experiments; Chapter Six: Investigation of Anesthetic-Protein Interactions by a Thermodynamic Approach; Abstract.
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8 |
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|a 1 Introduction2 ITC Measurements; 3 Conclusion; Chapter Seven: Electron Spin Resonance (EPR) in Drosophila and General Anesthesia; Abstract; 1 Introduction; 2 Electron Spin Resonance Primer; 3 Quantitation; 4 Sample Preparation; 5 Measurements; 6 Origin of the Spin Signal in Drosophila; 7 Conclusions; Chapter Eight: Giant Plasma Membrane Vesicles: An Experimental Tool for Probing the Effects of Drugs and Other Conditions on Membrane Domain Stability; Abstract; 1 Introduction; 2 GPMV Formation; 3 Measuring GPMV Miscibility Transition Temperatures; 4 Summary and Conclusion; Acknowledgments.
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|a Section III: In vivo Technologies Established and Evolving; Chapter Nine: Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs; Abstract; 1 Introduction; 2 Etomidate Analog Design Strategies; 3 Testing Novel Etomidate Analogs for Hypnotic Activity Using Loss of Righting Reflexes Assays; 4 Testing Novel Etomidate Analogs for Adrenocortical Inhibitory Activity; 5 Summary and Conclusion; Acknowledgments; Chapter Ten: Optoanesthesia: Use of Anesthetic Photolabels In Vivo; Abstract; 1 Introduction; 2 Anesthetic Photolabel Availability.
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| 650 |
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|a Anesthetics
|x Mechanism of action.
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| 650 |
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0 |
|a Anesthetics
|x Physiological effect.
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| 650 |
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7 |
|a MEDICAL
|x Surgery
|x General.
|2 bisacsh
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| 650 |
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7 |
|a Anesthetics
|x Mechanism of action.
|2 fast
|0 (OCoLC)fst00808705
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| 650 |
|
7 |
|a Anesthetics
|x Physiological effect.
|2 fast
|0 (OCoLC)fst00808707
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| 655 |
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4 |
|a Electronic books.
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| 700 |
1 |
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|a Eckenhoff, Roderic G.,
|e editor.
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| 700 |
1 |
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|a Dmochowski, Ivan J.,
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|t Chemical and biochemical approaches for the study of anesthetic function. Part B.
|b First edition.
|d Cambridge, MA : Academic Press, an imprint of Elsevier, 2018
|z 0128145749
|z 9780128145746
|w (OCoLC)1007038716
|
| 830 |
|
0 |
|a Methods in enzymology ;
|v v. 603.
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| 856 |
4 |
0 |
|3 ScienceDirect
|u https://www.sciencedirect.com/science/bookseries/00766879/603
|z Full Text via HEAL-Link
|
