Human Embryonic Stem Cells in Development /
Human Embryonic Stem Cells in Development, Volume 129, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as recapitulating pancreas development from human embryonic stem...
| Κύριος συγγραφέας: | |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cambridge, MA :
Academic Press, An imprint of Elsevier,
2018.
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| Έκδοση: | First edition. |
| Σειρά: | Current topics in developmental biology ;
v. 129. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Front Cover; Human Embryonic Stem Cells in Development; Copyright; Contents; Contributors; Preface; Chapter One: Modeling Mammalian Gastrulation With Embryonic Stem Cells; 1. Introduction; 2. Mathematical Preliminaries; 3. Colony Architecture; 3.1. Growth in Two-Dimensional Micropatterns; 3.2. Three-Dimensional Culture Systems; 4. Spatial Patterning of Cell Fates; 4.1. Micropatterned Two-Dimensional Culture Systems; 4.2. Three-Dimensional Culture Systems; 5. Conclusions; Acknowledgment; References; Chapter Two: What Can Stem Cell Models Tell Us About Human Germ Cell Biology?; 1. Introduction
- 2. Signaling for Germ Cell Specification in Mammalian Embryos3. Permissive Cell State for Germ Cell Specification in the Embryo; 4. Inducing Germline Competency in Pluripotent Stem Cells; 5. Transcription Factors for Human Germ Cell Specification and Epigenetic Resetting; 6. In Vitro Germ Cell Induction Beyond PGC Specification; 7. Misregulation of Germ Cell Development; 7.1. Germ Cell Tumors; 7.2. Inheritance of Epigenetic Mutations Through the Germline; 7.3. Inheritance of Mitochondria Through the Female Germline; 8. Perspective; Acknowledgments; References; Further Reading
- Chapter Three: From Human Pluripotent Stem Cells to Cortical Circuits1. Introduction; 2. Conserved Features of Mammalian Corticogenesis; 2.1. Early Cortical/Telencephalic Induction: It Is All in the Beginning; 2.2. Cortical Neurogenesis: In Vitro Generation of a Complex Repertoire of Cortical Neurons; 2.2.1. Pyramidal Neurons; 2.2.2. Cortical Interneurons; 3. Cortical Organoids: Adding a New Dimension in Cortical Modeling; 4. Divergent Features of Corticogenesis; 4.1. Temporal Dynamics of Corticogenesis; 4.2. Progenitor Diversity
- 5. Modeling Early Neurodevelopmental Disorders Striking the Human Cortex5.1. Primary Microcephaly; 5.2. Lissencephaly; 5.3. Macrocephaly; 6. Modeling Late Neurodevelopment of the Human Cortex; 6.1. Diseases Affecting Neuronal Maturation and Synapse Formation; 6.2. Evolution and Neoteny in the Human Cortex; 7. Conclusion and Perspective; Acknowledgments; References; Further Reading; Chapter Four: Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease; 1. Introduction; 2. Directed Differentiation of Human CNS Cell Types From iPSCs
- 2.1. Making Brain Cells in 2D2.2. 3D Human Brain Models: Patterned and Unpatterned Models; 3. Future Prospects for Improved 3D Brain Models; 4. Modeling Neuropsychiatric Disease In Vitro; 5. 2D and 3D Models of Neuropsychiatric Disease; 6. Conclusions; References; Chapter Five: The Long Road to Making Muscle In Vitro; 1. Overview of Muscle Development; 2. Sox2+/T+ Neuromesodermal Progenitors (NMPs) Represent the First Step in Myogenic Differentiation In Vitro; 3. PSM Formation From NMPs; 4. Crossing the Determination Front
