Epigenetics and psychiatric disease /
Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic...
| Άλλοι συγγραφείς: | |
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| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
London ; San Diego, CA :
Academic Press,
[2018]
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| Σειρά: | Progress in molecular biology and translational science ;
v. 157. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Cover; Title Page; Copyright page; Contents; Contributors; Preface; Chapter One
- Epigenetic Landscapes of the Adversity-Exposed Brain; Abstract; 1 Introduction; 1.1 Early Adversity, Epigenetics, and Psychiatric Disorder; 1.2 DNA Methylation; 2 Specificity of experience-induced methylation changes; 2.1 Tissue Specificity; 2.2 Cell-type Specificity; 3 Beyond methylation; 3.1 DNA Hydroxymethylation; 3.2 Early Adversity and the Hydroxymethylome; 4 Sex differences; 4.1 Animal Models; 4.2 Humans; 5 Methylation across the lifespan; 6 What we do not know and how we get there
- 6.1 Tissue- and Cell-type Specificity6.2 Hydroxymethylation and Non-CG Methylation; 6.3 Sex Differences; 6.4 Lifespan Methylation; 7 Concluding remarks; Acknowledgements; References; Chapter Two
- Chromosomal Conformations and Epigenomic Regulation in Schizophrenia; Abstract; 1 Introduction to the epigenomics of schizophrenia; 2 Regulation of chromosomal conformations in neurodevelopment; 2.1 Building Blocks of the 3D Genome; 2.2 Chromosomal Scaffolding Protein Mutations and Neuropsychiatric Disease; 3 Loop disruptions potentially involved in schizophrenia: early findings
- 3.1 Promoter-Enhancer Loops and Transcriptional Regulation3.2 Evidence for Loop Disruption in Brains of Subjects With Schizophrenia; 4 (EPI)Genomic editing of loop-bound regulatory sequences in the preclinical model; 5 Future directions; Acknowledgment; References; Chapter Three
- Progress in Epigenetics of Depression; Abstract; 1 Introduction; 2 Overview of epigenetic mechanisms; 2.1 DNA Methylation; 2.2 Chromatin Modifications; 2.3 Noncoding RNAs; 2.4 3D Chromatin Structure; 3 Methods for studying epigenetics and depression; 4 DNA methylation in depression
- 5 Histone modifications in depression5.1 Histone Acetylation; 5.2 Histone Methylation; 6 Chromatin remodeling in depression; 7 Regulation of the 3D genome in depression; 8 Noncoding RNAs in depression; 9 Conclusions; Acknowledgments; References; Chapter Four
- Epigenetics of Circadian Rhythms in Imprinted Neurodevelopmental Disorders; Abstract; 1 DNA methylation; 2 Long, noncoding RNAs; 3 Neurodevelopmental disorders involving imprinting and circadian rhythms; 3.1 Prader-Willi and Angelman Syndromes; 3.2 Kagami-Ogata and Temple Syndromes; 4 Mechanisms of imprinting in neurodevelopment
- 5 Circadian rhythms and imprinting in neurodevelopment6 Chronotherapeutics; Acknowledgements; References; Chapter Five
- The Role of DNA Methylation in Drug Addiction: Implications for Diagnostic and Therapeutics; Abstract; 1 Introduction; 2 Animal models of drug addiction; 3 DNA methylation in animal models of drug addiction; 4 Alterations in DNA methylation associated with drug addiction in human; 5 DNA methylation as a biomarker; 6 Future directions; Acknowledgments; References; Chapter Six
- DNA Methylation in Animal Models of Psychosis; Abstract
