Neuroepigenetics and mental illness /

• Άλλοι συγγραφείς: Rutten, Bart P. F. (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cambridge, MA : Academic Press, an imprint of Elsevier, [2018]
• Σειρά: Progress in molecular biology and translational science ; v. 158.
• Θέματα: Mental illness > Genetic aspects.; Mental illness > Physiological aspects.; Neurogenetics.; Epigenetics.; HEALTH & FITNESS > Diseases > General.; MEDICAL > Clinical Medicine.; MEDICAL > Diseases.; MEDICAL > Evidence-Based Medicine.; MEDICAL > Internal Medicine.; Electronic books.

Πίνακας περιεχομένων:

• Front Cover; Neuroepigenetics and Mental Illness; Copyright; Contents; Contributors; Chapter One: Neuroepigenetics of Mental Illness: The Inside Outs of the Outside Within; 1. The Epigenetic Machinery; 2. The Nature of Mental Disorders; 2.1. Complexity of Developmental Programming and the Brain; 2.2. Complexity of Dynamic, Rather Than Static, Concepts of Mental Illness; 3. An Integrative and Dynamic Conceptual Model; 4. Future Perspectives; References; Chapter Two: Methodologies of Neuroepigenetic Research: Background, Challenges and Future Perspectives; 1. Introduction
• 2. Methodologies of Neuroepigenetic Research2.1. DNA Methylation and Hydroxymethylation; 2.2. Histone Modifications; 2.3. Non-Coding RNAs; 3. Challenges and Future Perspectives; 3.1. Technological Issues; 3.2. Tissue and Cell-Type Specificity; 3.3. Causality; 3.4. Study Design; 3.5. Analytical Techniques; 4. Conclusion; References; Chapter Three: An Introduction to Epigenetic Mechanisms; 1. Introduction; 1.1. Epigenetic Mechanisms and Neurodevelopment; 2. Epigenetic Mechanisms of Regulation; 2.1. DNA Methylation; 2.1.1. DNA Methylation and Transcriptional Control; 2.2. DNA Hydroxymethylation
• 2.3. Histone Modifications2.4. Non-coding RNA; 3. Genomic Imprinting; 4. Reprogramming of Epigenetic Marks During Development; 4.1. Histone Modifications and Epigenetic Reprogramming; 4.2. Reprogramming of DNA Methylation; 5. Epigenetic Inheritance; 6. Concluding Remarks; Acknowledgment; References; Chapter Four: Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders; 1. Neuroepigenetics of Aging; 1.1. Alterations in DNA Modifications With Age; 1.2. Alterations in Chromatin Modifications During Aging; 1.3. Changes in Non-Coding RNAs
• 2. Neuroepigenetics of Age-Related Neurodegenerative Disorders2.1. Epigenetic Alterations in Alzheimer's Disease; 2.1.1. AD-Related DNA Modifications; 2.1.2. AD-Related Chromatin Modifications; 2.1.3. Alterations in Non-Coding RNAs in AD; 2.2. Epigenetic Alterations in Parkinson's Disease; 2.2.1. Alterations in DNA Modifications in PD; 2.2.2. Alterations in Chromatin Modifications in PD; 2.2.3. Alterations in Non-Coding RNAs in PD; 2.3. Epigenetic Alterations in Huntington's Disease; 2.3.1. Changes in DNA Modifications in HD; 2.3.2. Changes in Chromatin Modifications in HD
• 2.3.3. Changes in Non-Coding RNAs in HD3. Concluding Remarks; References; Chapter Five: Neuroepigenetics of Prenatal Psychological Stress; 1. Introduction; 1.1. The DOHaD Hypothesis; 1.2. Maternal Psychological Stress; 2. The Consequences of Prenatal Psychological Stress; 2.1. Animal Studies; 2.2. Human Studies; 2.2.1. Prenatal Stress and Internalizing Psychopathology; 2.2.2. Prenatal Stress and Externalizing Psychopathology; 2.2.3. Prenatal Stress and Other Mental Disorders; 2.2.4. Underlying Endophenotypes and Neurobiological System Changes