Membranes in Pulmonary Vascular Disease /
Membranes in Pulmonary Vascular Disease, Volume 82, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters from recognized experts on topics such as Sphingolipids in Vascular Lung Disease, Endothelial G...
| Άλλοι συγγραφείς: | , |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cambridge, MA :
Academic Press,
2018.
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| Έκδοση: | First edition. |
| Σειρά: | Current topics in membranes ;
v. 82. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Front Cover; Membranes in Pulmonary Vascular Disease; Copyright; Contents; Contributors; Preface; Chapter One: Sphingolipids Signaling in Lamellipodia Formation and Enhancement of Endothelial Barrier Function; 1. Introduction; 2. Dynamics of Lamellipodia; 3. Modulation of Lung Endothelial Barrier Function by Inflammatory and Protective Agents; 4. Mechanisms of Lamellipodia Formation and Endothelial Barrier Enhancement; 4.1. Sphingosine Kinase/Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptors Signaling and Focal Adhesions in Barrie ...
- 4.2. S1P Analogs, FTY720, FTY720-P, and FTY-720 Phosphonate, and Endothelial Barrier Enhancement4.3. HGF/c-Met/PI3K/Akt Signaling in Lamellipodia Formation and Endothelial Barrier Enhancement; 4.4. Cross-Talk Between HGF/c-Met and SPHK1/S1P/S1PR Signaling in Lamellipodia Formation and Endothelial Barrier Enhancement; 5. Reactive Oxygen Species, Lamellipodia Formation, and Endothelial Barrier Enhancement; 6. Oxidized Phospholipids, Lamellipodia Formation, and Endothelial Barrier Enhancement; 7. Simvastatin Activation of S1P1 in Endothelial Barrier Enhancement
- 8. Conclusions and Future DirectionsAcknowledgments; References; Chapter Two: The Pulmonary Endothelial Glycocalyx in ARDS: A Critical Role for Heparan Sulfate; 1. Emerging Understanding and Historical Underappreciation of Endothelial Glycocalyx Structure and Function; 2. Polysaccharide Structure of the Endothelial Glycocalyx: A Focus on HeparanSulfate; 3. Pulmonary Endothelial Glycocalyx Heparan Sulfate Is Essential for Lung Homeostasis; 4. Fate of Glycocalyx Heparan Sulfate During Sepsis-Induced ARDS Onset and Resolution
- 4.1. Sepsis-Associated Pulmonary Endothelial Glycocalyx Degradation Mediates Lung Injury Onset4.2. Sepsis-Associated Impairment of Heparan Sulfate Reconstitution Prolongs Lung Injury After Sepsis; 5. Multisystemic Consequences of Glycocalyx Degradation; 5.1. Multisystemic Effects of Heparanase Induction; 5.2. Multisystemic Effects of Heparan Sulfate Fragments Released During Glycocalyx Degradation; 6. Unanswered Questions: The Endothelial Glycocalyx in Direct vs. Indirect LungInjury; 7. Summary; References; Chapter Three: Cholesterol Regulation of Pulmonary Endothelial Calcium Homeostasis
- 1. Introduction2. Endothelial Ca Channels in the Pulmonary Circulation; 2.1. Functional Roles of Ca in Pulmonary Endothelium; 2.2. Modes of Pulmonary Endothelial Ca Entry; 2.2.1. Store-Operated Ca Entry; 2.2.2. Receptor-Operated Ca Entry; 2.2.3. Depolarization-Induced Ca Entry; 3. Hypoxic Regulation of Pulmonary Endothelial Ca Entry; 4. Role of Membrane Cholesterol in Regulating Endothelial Ca Entry in CH-Induced PH; 4.1. CH Impairs Endothelial Ca Influx by Reducing Membrane Cholesterol; 4.2. Role of Caveolin-1 in Regulating Endothelial Ca Entry
