Advances in heterocyclic chemistry. Volume 127.

• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: [Place of publication not identified] : Elsevier Academic Press, 2019.
• Σειρά: Advances in Heterocyclic Chemistry ; v. 127.
• Θέματα: Heterocyclic chemistry.; SCIENCE > Chemistry > Organic.; Electronic books.

Πίνακας περιεχομένων:

• Front Cover; Advances in Heterocyclic Chemistry; Copyright; Contents; Contributors; Preface; Chapter One: Recent advances in 1,2,4-triazolo[1,5-a]pyrimidine chemistry; 1. Introduction; 1.1. General survey; 1.2. Scope and limitation; 1.3. Nomenclature; 2. Occurrence and synthesis; 2.1. Survey; 2.2. Occurrence; 2.3. Syntheses from 5-amino-1,2,4-triazoles and 1,3-biselectrophiles; 2.3.1. Principle and conditions; 2.3.2. The diversity of biselectrophiles; 2.3.3. Regioselectivity; 2.3.4. The direct synthesis of triazolopyrimidines substituted onto carbon ring atoms
• 2.3.5. The use of modified biselectrophiles2.3.6. The use of polyfunctional electrophiles; 2.3.7. Syntheses via dihydro triazolopyrimidines; 2.3.8. Multicomponent reactions; 2.3.9. Special syntheses; 2.4. Syntheses using special aminotriazole derivatives; 2.4.1. Syntheses of N-substituted triazolopyrimidines; 2.4.2. The use of aminotriazole-based intermediates; 2.5. Triazole ring syntheses; 2.5.1. Syntheses from 1,2-diaminopyrimidines; 2.5.2. Syntheses from N-(pyrimid-2-yl)amidine-series compounds; 2.5.3. Syntheses from 2-hydrazinopyrimidines; 2.5.4. Other triazole ring syntheses
• 2.6. Other routes to triazolopyrimidines2.6.1. Aromatization of dihydro derivatives; 2.6.2. Ring transformation and cleavage; 3. Structure; 3.1. Theoretical methods; 3.2. X-ray diffraction; 3.3. Molecular spectra; 3.3.1. H NMR spectra; 3.3.2. C NMR spectra; 3.3.3. F NMR spectra; 3.3.4. Electronic spectra; 3.3.5. Infrared and Raman spectra; 3.3.6. Mass spectra; 3.4. Physicochemical properties; 3.5. Tautomerism; 4. Reactivity; 4.1. Triazolopyrimidines as bases and acids; 4.1.1. Protonation and dissociation; 4.1.2. Coordination; 4.2. Alkylation at nitrogen ring atoms
• 4.3. Carbon-carbon coupling at ring atoms4.3.1. The use of organometallic and metal salt reagents; 4.3.2. Suzuki coupling; 4.3.3. Sonogashira coupling; 4.3.4. Oxidative coupling; 4.3.5. Reductive coupling; 4.3.6. Nucleophilic addition; 4.4. Other reactions at ring atoms; 4.5. Nucleophilic substitution of functional groups at the rings; 4.5.1. Substitution of halogen; 4.5.2. Substitution of oxygen-, sulfur-, or nitrogen-containing functions; 4.6. Transformation of individual substituents; 4.6.1. Oxygen- or sulfur-containing groups; 4.6.2. Amines and their derivatives
• 4.6.3. Carbonyl containing groups4.7. Ring cleavage and recyclization; 4.8. Anellation of heterocyclic rings; 4.8.1. Anellation onto 6/7 positions; 4.8.2. Anellation onto other positions; 4.9. Reactivity of side chains; 4.9.1. Reactions involving halogen or oxygen functionalities; 4.9.2. Reactions involving sulfur, nitrogen, or phosphorus functionalities; 4.9.3. Formation of hydrocarbon groups; 4.9.4. Formation of diheterocyclyl compounds; 5. Application; 5.1. Pharmaceutical use; 5.2. Agrochemical use; 5.3. Optical and information recording uses; 5.4. Other uses; References