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190123s2019 mau ob 000 0 eng d |
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|a Aldosterone /
|c [edited by] Gerald Litwack.
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|a First edition.
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1 |
|a Cambridge, MA, United States :
|b Academic Press,
|c 2019.
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|a 1 online resource
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
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|a Vitamins and Hormones ;
|v 109
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|a Includes bibliographical references.
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|a Online resource; title from PDF title page (EBSCO, viewed January 30, 2019).
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|a Aldosterone, Volume 109, the latest release in the Vitamins and Hormones series first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics relating to Aldosterone Research, Aldosterone and Micrornas, the Evolution of the Mineralocorticoid Receptor, Aldosterone and Kidney Micrornas, Adipocyte Mineralocorticoid Receptor, Regulation of Aldosterone Secretion, Leptin and Aldosterone, Cell- and Ligand-Specific Interactions in Mineralocorticoid Receptor Signaling, Primary Aldosteronism, Present and Future, Aldosterone-Producing Adenomas, Overexpression of the Mineralocorticoid Receptor, Aldosterone and Myocardial Pathology, and much more.
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|a Intro; Title page; Table of Contents; Copyright; Former Editors; Contributors; Preface; Chapter One: Aldosterone Research: 65 Years, and Counting; Abstract; Chapter Two: Evolution of the Mineralocorticoid Receptor; Abstract; 1 Introduction; 2 The MR Consists of Multiple Functional Domains; 3 Evolution of the MR Steroid-Binding Domain; 4 Aldosterone, the Terrestrial Vertebrate Mineralocorticoid, Is at the End of the Pathway for Corticosteroid Synthesis; 5 Diverse Steroids Have High Affinity for the MR; 6 Diverse Steroids Have Different Transcriptional Activity for the MR
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|a 7 An Evolutionary Puzzle: Progesterone Is a MR Antagonist in Humans and a MR Agonist in Ray-Finned Fish8 Conclusion; Acknowledgment; Conflict of Interest; Funding; Author Contributions; Chapter Three: Mechanisms of Mineralocorticoid Receptor Signaling; Abstract; 1 Introduction; 2 Target Tissues and Ligand Access; 3 MR Structure and Function; 4 The Ligand-MR Interaction; 5 An Interaction Between the NTD and the LBD: The N/C-Interaction; 6 DNA Binding; 7 Coregulators for the MR; 8 Conclusions; Acknowledgments; Conflict of Interest; Chapter Four: Regulation of Aldosterone Signaling by MicroRNAs
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|a Abstract1 Introduction to Non-Coding RNAs; 2 MiR Production; 3 Regulation of MiR Expression by Aldosterone; 4 MiR Regulation of Aldosterone Signaling; 5 Regulation of Related Steroid Hormone Signaling by MiRs; 6 MiR Role in Modulating Aldosterone Effects in the Kidney; 7 MiR Regulation of Other Kidney Transporters and Regulatory Proteins; 8 MiRs in Aldosterone-Related Disease; Acknowledgments; Chapter Five: Aldosterone and Ion Channels; Abstract; 1 Introduction; 2 Sodium Channels; 3 Potassium Channels; 4 Calcium Channels; 5 Chloride Channels; 6 Conclusions and Future Directions
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|a AcknowledgmentsChapter Six: Non-Genomic Effects of Aldosterone; Abstract; 1 Introduction; 2 Extra-Nuclear, Non-Genomic Actions Linked to Genomic Actions of Aldosterone; 3 Role of Second Messenger Pathways; 4 Controversy of Which Receptor Involved in Non-Genomic Actions of Aldosterone; 5 Gender Differences in MR Activation: Modeling Sex Hormone-MR Interactions; 6 Conclusion; Chapter Seven: Mineralocorticoid Receptor Antagonists; Abstract; 1 Clinical Use of Mineralocorticoid Receptor Antagonists; 2 Specific Challenges in Designing Mineralocorticoid Receptor Antagonists
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|a 3 MR Antagonists That Fit in the Aldosterone Binding Site4 MR Antagonists That Utilize the Met852 Pocket; 5 The Helix 6-7 Induced Pocket; 6 Aromatic Sulfonamides as MR Antagonists; 7 Pyrrole Derivatives as MR Antagonists; 8 The 1,4-Dihydropyridine Class of MR Antagonists; 9 The Pyrazoline Class of MR Antagonists; 10 Oxazolidinone Derivatives as MR Antagonists; 11 MR Antagonists With a Tricyclic Scaffold; 12 Summary; Chapter Eight: Adipocyte Mineralocorticoid Receptor; Abstract; 1 Introduction: The Adipose Organ; 2 Adipocyte Mineralocorticoid Receptor (MR) and Adipogenesis
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|a Aldosterone.
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|a Aldosterone.
|0 (DNLM)D000450
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|a MEDICAL
|x Pharmacology.
|2 bisacsh
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|a Aldosterone.
|2 fast
|0 (OCoLC)fst00804681
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|a Electronic books.
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| 700 |
1 |
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|a Litwack, Gerald,
|e editor.
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| 776 |
0 |
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|i Print version:
|t Aldosterone.
|b First edition.
|d Cambridge, MA, United States : Academic Press, 2019
|z 0128177829
|z 9780128177822
|w (OCoLC)1044858216
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| 856 |
4 |
0 |
|3 ScienceDirect
|u https://www.sciencedirect.com/science/bookseries/00836729/109
|z Full Text via HEAL-Link
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