Organ development /
'Organ Development, ' Volume 132, in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapter written by an international board of authors. This volume highlights cogent reviews of the development, mainten...
| Άλλοι συγγραφείς: | |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cambridge, MA :
Academic Press, an imprint of Elsevier,
[2019]
|
| Έκδοση: | First edition. |
| Σειρά: | Current topics in developmental biology ;
v. 132. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Front Cover; Organ Development; Copyright; Contents; Contributors; Preface; A Note About the Authors; Chapter One: Chasing Mavericks: The quest for defining developmental waves of hematopoiesis; 1. Introduction; 2. HSC emergence: Where, when, and how?; 2.1. Cellular origins of HSCs: Hemangioblast versus hemogenic endothelium; 2.2. Are HSCs specified multiple times in distinct locations?; 3. Molecular regulation of HSC specification; 3.1. What are the molecular drivers of HSC specification and maintenance?; 4. Phenotypic and functional heterogeneity within the HSPC pool
- 4.1. Extensive transcriptome heterogeneity of cell populations4.2. Functional heterogeneity of hematopoietic progenitor populations; 4.3. Do all HSCs persist?; 5. Purpose of developmental waves; 5.1. Immune system layering; 6. Conclusion and future directions; Acknowledgments; Author contributions; Competing interests; References; Further reading; Chapter Two: Signals and forces shaping organogenesis of the small intestine; 1. Generation and growth of the intestinal tube; 1.1. Embryonic origins of the murine small intestine; 1.2. Shaping the intestinal tube
- 1.3. Formation of the convoluted intestinal tract1.4. Intestinal elongation; 2. Patterning and regionalization; 2.1. The pylorus: The anterior intestinal boundary; 2.2. Signaling crosstalk: Endoderm/mesoderm interactions in gut tube patterning; 2.3. Regionalization within the small intestine: Duodenum, jejunum, and ileum; 3. Villus development; 3.1. Signals and physical forces driving formation of the villi; 3.2. Mesenchymal factors controlling villus development; 3.3. Epithelial factors important in villus emergence; 4. Making crypts; 5. Organoid systems to study intestinal development
- 6. SummaryReferences; Chapter Three: Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells; 1. Overview: Lung as a sensory organ; 2. PNEC lineage origin and specification; 3. PNEC innervation; 4. PNECs in lung development; 5. PNEC function as progenitors and progenitor niches; 6. PNEC function in response to airway inputs; 6.1. As an immune modulator; 6.2. Activation by hypoxia, carbon dioxide and acid; 6.3. Activation by nicotine; 6.4. Activation by stretch; 7. PNECs in chronic lung diseases; 8. Pulmonary neuroendocrine cells in cancer; 9. Concluding remarks
