Nucleic acid sensing and immunity. Part A /

• Άλλοι συγγραφείς: Vanpouille-Box, Claire (Επιμελητής έκδοσης), Galluzzi, Lorenzo (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cambridge, MA, United States : Academic Press, 2019.
• Έκδοση: First edition.
• Σειρά: International review of cell and molecular biology ; v. 344.
• Θέματα: Nucleic acids.; Nucleic acids > Regulation.; RNA.; SCIENCE > Life Sciences > Biology.; Electronic books.

 'Nucleic Acid Sensing and Immunity - PART A, ' Volume 344, provides a comprehensive overview of the nucleic acid machinery, from plants to mammalians, as well as their regulation. Specific chapters in this updated release include Molecular bases of discrimination between self from non-self nucleic acids, Intracellular RNA sensing in mammalian cells, Nuclear DNA damage and nucleic acid sensing, Negative regulation of nucleic acid sensing, Dendritic cell responses to exogenous nucleic acids, Activating the nucleic acid-sensing machinery for anticancer immunity, and Nucleic acid sensing and inflammasomes, amongst other topics. Key Features: Provides an accurate, state-of-the-art resource on RNA sensing; Includes the work of a well-known tumor immunologist; Links intestinal host defense and viral nucleic acid sensing; Presents a chapter on the negative regulation of DNA sensing, a timely topic. Readership: Immunologists to tumor immunologists and DNA damage biologists. --   Provided by publisher. 

 Front Cover; Nucleic Acid Sensing and Immunity, Part A; Copyright; Contents; Contributors; Nucleic Acid Sensing at the Interface Between Innate and Adaptive Immunity; Acknowledgments; Disclosures; References; Chapter One: Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System; 1. Introduction; 2. Intracellular Nucleic Acid Sensors; 2.1. RLRs; 2.2. ALRs; 2.3. cGAS; 2.4. ISGs; 3. Extracellular Nucleic Acid Recognition; 3.1. TLRs; 3.2. TLR9; 3.3. TLR3; 3.4. TLR7 and TLR8; 4. Modifications Enabling DNA Discrimination; 4.1. APOBEC3; 4.2. SAMHD1