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on1096190294 |
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20200326101200.0 |
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m o d |
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190409s2019 xx o 000 0 eng d |
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|a OPELS
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|a (OCoLC)1096190294
|z (OCoLC)1096470679
|z (OCoLC)1122747433
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|a QL381
|b .E24 2019eb
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|a 593.9
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|a Echinoderms.
|n Part B /
|c edited by Amro Hamdoun, Kathy R. Foltz.
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| 264 |
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1 |
|a [Place of publication not identified] :
|b Academic Press,
|c 2019.
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| 300 |
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|a 1 online resource
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Methods in cell biology ;
|v volume 151
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|a Title from title details screen.
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|a Front Cover; Echinoderms, Part B; Copyright; Contents; Contributors; Preface; Dedication; Coverblurb; 1: Fertilization; When sperm meets egg-Fifty years of surprises; Introduction; Cell biology in the late 1950s and early 1960s; My thesis problem circa 1959-control of the cell cycle; Control of the cell cycle circa today; How I became interested in fertilization; A wrong hypothesis directs me to a new area; My new field; Protein synthesis; A serendipitous finding leads to a new areacortical granules; The rest of the story on egg activation at fertilization
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|a What are exciting areas for future research?References; Early and later studies on action potential and fertilization potential of echinoderm oocytes and Ca2+ re; References; My research career on (mainly) sea urchins; Getting hooked on a career in research; What led me into echinoderms?; How did I begin studying fertilization?; My most exciting finding; One important conceptual contribution of my lab; The most satisfying part of my career; Enter the new biology; Advice for people just beginning their careers; References; 2: Cytokenesis and embryology
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|a Echinoderm eggs as a model for discoveries in cell biologyEarly cell biological work: Microscopy; Biochemistry of the cytoskeleton; Live cell imaging, biochemistry and cell manipulations; Super resolution imaging, live cell fluorescent imaging and mathematical modeling; Acknowledgments; References; Unlocking mechanisms of development through advances in tools; From hemoglobin to urchin spicules; 3: Genomics and morphogenesis; The causes of things; References; A personal history of the echinoderm genome sequencing; References; Section I: Methods for genome and transcriptome analysis
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|a Chapter 1: Genomic resources for the study of echinoderm development and evolution1. Introduction; 2. Genome assembly; 3. Gene prediction and annotation; 4. Transcriptome assembly and quantitation; 5. Functional genomic analyses; 6. Other tools and resources; 6.1. BAC resources; 6.2. GRNs and BioTapestry; 7. Adding data to EchinoBase; 8. Conclusions; Acknowledgments; References; Chapter 2: Methods for the experimental and computational analysis of gene regulatory networks in sea urchins; 1. Introduction; 2. Experimental analysis of gene regulatory networks
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|a 2.1. Identification of transcriptional regulators2.2. Identification of functional regulatory interactions by trans-perturbation; 2.2.1. Strategies for perturbation of regulatory factors; 2.2.2. Approaches for identification of target genes; 2.3. Identification of functional regulatory interaction by cis-perturbation; 2.3.1. Identification of active CRMs; 2.3.2. Identification of cis-regulatory inputs; 2.4. Physical interaction between transcription factors and DNA-binding site; 3. A strategy for data analysis and modeling of gene regulatory networks
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| 650 |
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|a Echinodermata.
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| 650 |
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7 |
|a SCIENCE
|x Life Sciences
|x Zoology
|x General.
|2 bisacsh
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| 650 |
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|a Echinodermata.
|2 fast
|0 (OCoLC)fst00901339
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| 655 |
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|a Electronic books.
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| 700 |
1 |
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|a Hamdoun, Amro,
|e editor.
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| 700 |
1 |
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|a Foltz, Kathleen,
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|t Echinoderms. Part B.
|d [Place of publication not identified] : Academic Press, 2019
|z 0128170727
|z 9780128170724
|w (OCoLC)1052876605
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| 830 |
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0 |
|a Methods in cell biology ;
|v v. 151.
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| 856 |
4 |
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|3 ScienceDirect
|u https://www.sciencedirect.com/science/bookseries/0091679X/151
|z Full Text via HEAL-Link
|
