The Proteasome in Neurodegeneration

• Corporate Author: SpringerLink (Online service)
• Other Authors: Stefanis, Leonidas (Editor), Keller, Jeffrey N. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2006.
• Subjects: Medicine.; Neurosciences.; Cell biology.; Biomedicine.; Cell Biology.

"Protein degradation, especially via the ubiquitin-proteosome system, has emerged as a critical molecular component to mechanisms of cell death in a variety of prominent neurodegenerative diseases. Thus, the editors of this book should be praised for the comprehensiveness and timeliness of thei...

Table of Contents:

• Basic Aspects of Protein Degradation Through the Ubiquitin Proteasome System (UPS)
• Yeast Proteasome Structure and Biogenesis
• Ubiquitin-Proteasome System in the Central Nervous System
• Protein Aggregation, Inclusion Formation and Ups Function
• Protein Aggregation and the UPS: A Two-Way Street
• The Impact of Inclusion Formation on Cell Survival
• Inclusion Formation and Disolution Following Proteasomal Inhibition in Neuronal Cells
• Oxidative Stress and Ups Function
• The Proteasome: Source and a Target of Oxidative Stress?
• Inflammation as a Mediator of Oxidative Stress and UPS Dysfunction
• Proteasome and Neuronal Cell Death and Survival
• Role of the Ubiquitin Proteasome System During Neuronal Cell Death
• Pathways of Neuronal Cell Death Induced by Proteasomal Inhibition
• Models of Dysfunction of the UPS and the Proteasome
• Pharmacological and Molecular Models of Proteasomal Dysfunction
• The Gad Mouse: A Window Into UPS-Related Neurodegeneration and the Function of the Function of the Deubiquitinating Enzyme Uch-L1
• The UPS in Neurodegenerative Diseases and Aging
• Parkinson’s Disease and Related Disorders
• Ubiquitination by Parkin — Implications in Parkinson’s Disease
• The Ups in Neurodegenerative Diseases and Aging Huntington’s Disease
• Frameshift Mutant Ubiquitin in Alzheimer’s Disease and Other Neurodegenerative Disorders
• Motor Neuron Disease
• The Paradoxical Role of Proteasomes in Prion Disorders
• Aging and the Proteasome.