Neurochemical Aspects of Excitotoxicity

• Main Authors: Farooqui, Akhlaq A. (Author), Ong, Wei-Yi (Author), Horrocks, Lloyd A. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2008.
• Subjects: Medicine.; Neurosciences.; Medical biochemistry.; Neurology.; Biochemistry.; Biomedicine.; Biochemistry, general.; Medical Biochemistry.

About 40% of central nervous system synapses use glutamate as the neurotransmitter. Over-stimulation of glutamate receptors produces neuronal injury or death by excitotoxicity, which is closely associated with neurochemical and neuropathological changes involved in acute neural trauma (stroke, spina...

Table of Contents:

• Glutamate and Aspartate in Brain
• Excitatory Amino Acid Receptors in Brain
• Multiplicity of Glutamate Receptors in Brain
• Glutamate Transporters and Their Role in Brain
• Excitatory Amino Acid Receptors and Their Association with Neural Membrane Glycerophospholipid Metabolism
• Glutamate Receptors and Their Association with Other Neurochemical Parameters in Excitotoxicity
• Possible Mechanisms of Neural Injury Caused by Glutamate and Its Receptors
• Glutamate Receptors and Neurological Disorders
• Endogenous Antioxidant Mechanisms and Glutamate Neurotoxicity
• Glutamate Receptor Antagonists and the Treatment of Neurological Disorders
• Future Perspectives: New Strategies for Antagonism of Excitotoxicity, Oxidative Stress and Neuroinflammation in Neurodegenerative Diseases.