The Sarcomere and Skeletal Muscle Disease

• Corporate Author: SpringerLink (Online service)
• Other Authors: Laing, Nigel G. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2008.
• Series: Advances in Experimental Medicine and Biology, 642
• Subjects: Medicine.; Human physiology.; Biomedicine.; Biomedicine general.; Human Physiology.

Although best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-c...

Table of Contents:

• The Sarcomere and Sarcomerogenesis
• Skeletal Muscle Alpha-Actin Diseases
• Nebulin—A Giant Chameleon
• Skeletal Muscle Disease Due to Mutations in Tropomyosin, Troponin and Cofilin
• Investigations into the Pathobiology of Thin-Filament Myopathies
• Mouse Models for Thin Filament Disease
• Thick Filament Diseases
• Acute Quadriplegic Myopathy: An Acquired “Myosinopathy”
• Third Filament Diseases
• The Z-Disk Diseases
• Intermediate Filament Diseases: Desminopathy
• Muscular Integrity—A Matter of Interlinking Distinct Structures via Plectin
• The Sarcomere and the Nucleus: Functional Links to Hypertrophy, Atrophy and Sarcopenia
• Other Model Organisms for Sarcomeric Muscle Diseases
• Therapeutic Approaches for the Sarcomeric Protein Diseases.