Oxidation: The Cornerstone of Carcinogenesis Oxidation and Tobacco Smoke Carcinogenesis. A Relationship Between Cause and Effect /

• Main Author: Stavridis, John C. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2008.
• Subjects: Medicine.; Cancer research.; Human genetics.; Molecular biology.; Pharmacology.; Oncology.; Biomedicine.; Cancer Research.; Human Genetics.; Molecular Medicine.; Pharmacology/Toxicology.

In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the sp...

Table of Contents:

• Oxygen and Nitrogen Free Radicals
• Oxidative Stress
• Oxidative Damage of Genome DNA: Repair Mechanisms
• Mitochondria: Structure, Function and Relationship with Carcinogenesis
• Oxidative Activation of Transcription Factor Pathways by Cigarette Smoke Oxidants
• Cell Protection Mechanisms from Oxidation
• Role of DNA Adducts in Carcinogenesis
• Transmolecular Reactions of Genetic Toxicity: Alkylation and Methylation of DNA
• Toxicity and Carcinogenicity of Hydrocarbons
• Toxicity and Carcinogenicity of the Aromatic Hydrocarbons
• Toxicity and Carcinogenicity of Aldehydes
• Toxicity and Carcinogenicity of the Nitriles
• Toxicity and Carcinogenicity of the Eterocyclic Organic Compounds
• Toxicity and Carcinogenicity of Metals
• Oxidative Profile of Cigarette Smoke and Lung Cancer
• Smoking and Lung Cancer.