Development of Antibody-Based Therapeutics Translational Considerations /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Tabrizi, Mohammad A. (Editor), Bornstein, Gadi G. (Editor), Klakamp, Scott L. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2012.
• Subjects: Pharmacy.; Pharmacology.; Biochemistry.; Pharmacology/Toxicology.; Biochemistry, general.

Development of Antibody-Based Therapeutics: Translational Considerations examines important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics. Translational strategies for development of antibody-based therapeutics req...

Table of Contents:

• Translational Strategies for Development of Antibody-Based Therapeutics: An Overview
• Discovery Process for Antibody-Based Therapeutics
• Technologies for the Generation of Human Antibodies
• Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics
• Biophysical Considerations
• Considerations in Establishing Affinity Design Goals
• BioAnalytical Considerations: Pharmacokinetics and Immunogenicity
• Antibody-Based Therapeutics in Oncology : Preclinical Considerations
• Factors Impacting the Tumor Localization and Distribution
• Antibody-Based Therapeutics: Preclinical Safety Considerations
• Application of Pharmacokinetic/Pharmacodynamic Modeling
• Design of Translational Strategies : Application of Population Pharmacokinetic-Pharmacodynamic (PK-PD) Approaches
• Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics
• Development of Antibody-Based Therapeutics: Translational Research in Alzheimer’s Disease
• Considerations in Manufacturing Process Development
• Next Generation Antibody-Based Therapeutics
• Immune Complex Therapies for Treatment of Immune Thrombocytopenia (ITP)
• Application of Bioinformatics Principles for Target Evaluation
• Concluding Remarks.