Handbook of HER2-targeted agents in breast cancer

• Main Authors: Alvarez, Ricardo H. (Author), Cortés, Javier (Author), Mattos-Arruda, Leticia De (Author), Falzon, Mary (Author), Fasolo, Angelica (Author), Gandy, Michael (Author), Gianni, Luca (Author), Harbeck, Nadia (Author), Piccart, Martine (Author), Zambelli, Stefania (Author), Zardavas, Dimitrios (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Tarporley : Springer Healthcare Ltd. : Imprint: Springer Healthcare, 2013.
• Subjects: Medicine.; General practice (Medicine).; Internal medicine.; Oncology.; Primary care (Medicine).; Pharmacotherapy.; Medicine & Public Health.; Primary Care Medicine.; General Practice / Family Medicine.; Internal Medicine.

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year.  Of these cases, approximately  15–25% overexpress HER2, a transmembrane RTK kinase that is associated with aggress...

Table of Contents:

• Introduction and background biology
• HER2 testing
• HER2-positive breast cancer: adjuvant and neoadjuvant therapy
• HER2-positive metastatic breast cancer: first-line treatment
• HER2-positive metastatic breast cancer: second-line treatment
• Emerging targeted agents for HER2-positive breast cancer.