Thymus Transcriptome and Cell Biology

• Corporate Author: SpringerLink (Online service)
• Other Authors: Passos, Geraldo A. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Subjects: Systems biology.; Human genetics.; Endocrinology .; Cell biology.; Systems Biology.; Human Genetics.; Endocrinology.; Cell Biology.

This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial...

Table of Contents:

• 1. History of the thymus: From a vestigial organ to the programming of immunological self-tolerance
• 2. Thymus Ontogeny and Development
• 3. The Ins and Outs of Thymic Epithelial Cell Differentiation and Function
• 4. T-Cell Development: From T-Lineage Specification to Intrathymic Maturation
• 5. Intrathymic cell migration: implications in thymocyte development and T-cell repertoire formation
• 6. Thymic crosstalk: an overview of the complex cellular interactions that control the establishment of T-cell tolerance
• 7. The Autoimmune Regulator (AIRE) gene, the master activator of self-antigen expression in the thymus
• 8. Aire Mutations and Autoimmune Diseases
• 9. The thymus as a mirror of the body's gene expression
• 10. Functional genomics of the infant human thymus: Aire and minipuberty
• 11. Thymus transcriptome of TGF-β superfamily
• 12. Development of thymic regulatory T lymphocytes
• 13. Adding insult to injury: improving the regenerative capacity of the aged thymus following clinically induced damage
• 14. Thymus rejuvenation after autologous hematopoietic stem cell transplantation in patients with autoimmune diseases.