Direct Mechanisms in Cholesterol Modulation of Protein Function

• Corporate Author: SpringerLink (Online service)
• Other Authors: Rosenhouse-Dantsker, Avia (Editor, http://id.loc.gov/vocabulary/relators/edt), Bukiya, Anna N. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Advances in Experimental Medicine and Biology, 1135
• Subjects: Proteomics.; Proteins .; Cell membranes .; Molecular biology.; Protein Science.; Membrane Biology.; Molecular Medicine.

In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical featu...

Table of Contents:

• Introduction
• Direct binding of cholesterol to proteins
• Cholesterol-recognition motifs in membrane proteins
• Molecular determinants of cholesterol binding to proteins: overview of crystallographic studies
• Crystallographic studies of steroid-protein interactions
• Insights into cholesterol binding sites in proteins from computational studies
• Cholesterol binding to NPC1/NPC2
• I Biophysical elements of the interaction between cholesterol and the nicotinic acetylcholine receptor
• Modulation of TRPV1 channels by cholesterol
• Cholesterol binding sites in inwardly rectifying potassium channels.