The Nociceptin/Orphanin FQ Peptide Receptor

The Nociceptin/Orphanin FQ Peptide Receptor

The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for th...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Ko, Mei-Chuan (Editor, http://id.loc.gov/vocabulary/relators/edt), Caló, Girolamo (Editor, http://id.loc.gov/vocabulary/relators/edt)
Format: Electronic eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2019.
Edition:1st ed. 2019.
Series:Handbook of Experimental Pharmacology, 254
Subjects:
Pharmacology.
Neurosciences.
Anesthesiology.
Pain medicine.
Psychopharmacology.
Pharmacology/Toxicology.
Pain Medicine.
Online Access:Full Text via HEAL-Link
Table of Contents:
  • PART I. The N/OFQ-NOP Receptor System
  • 1. The History of N/OFQ and the NOP Receptor
  • 2. NOP-Targeted Peptide Ligands
  • 3. NOP-Targeted Nonpeptide Ligands
  • 4. Pharmacological Assays for Investigating the NOP Receptor
  • 5. Electrophysiological Actions of N/OFQ
  • 6. NOP Receptor Signaling Cascades
  • 7.Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor
  • PART II. Biological Actions of NOP Ligands
  • 8.NOP-Related Mechanisms in Pain and Analgesia
  • 9. NOP-Related Mechanisms in Substance Use Disorders
  • 10. NOP Receptor Ligands and Parkinson's Disease
  • 11. NOP Ligands for the Treatment of Anxiety and Mood Disorders
  • 12. The Nociceptin/Orphanin FQ System and the Regulation of Memory
  • 13. N/OFQ-NOP System in Food Intake
  • 14. N/OFQ-NOP System in Peripheral and Central Immunomodulation
  • 15. N/OFQ-NOP System and Airways
  • 16. Effects of NOP-Related Ligands in Nonhuman Primates
  • PART III. First Clinical Studies with NOP Ligands
  • 17. Nociceptin/Orphanin FQ and Urinary Bladder
  • 18. Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors
  • 19. Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094)
  • 20. Correction to: Electrophysiological Actions of N/OFQ.

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