The Inflammasomes

• Corporate Author: SpringerLink (Online service)
• Other Authors: Couillin, Isabelle (Editor), Pétrilli, Virginie (Editor), Martinon, Fabio (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Springer Basel, 2011.
• Series: Progress in Inflammation Research
• Subjects: Medicine.; Immunology.; Infectious diseases.; Enzymology.; Cytokines.; Growth factors.; Cell biology.; Biomedicine.; Infectious Diseases.; Cell Biology.; Cytokines and Growth Factors.

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene,...