The Inflammasomes

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Couillin, Isabelle (Επιμελητής έκδοσης), Pétrilli, Virginie (Επιμελητής έκδοσης), Martinon, Fabio (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Basel : Springer Basel, 2011.
• Σειρά: Progress in Inflammation Research
• Θέματα: Medicine.; Immunology.; Infectious diseases.; Enzymology.; Cytokines.; Growth factors.; Cell biology.; Biomedicine.; Infectious Diseases.; Cell Biology.; Cytokines and Growth Factors.

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene,...

Πίνακας περιεχομένων:

• Molecular definition of inflammasomes
• Pyroptosis: A Caspase-1-dependent programmed cell death and a barrier to infection
• Activation of the inflammasome by bacterial pathogens
• The Role of Inflammasomes in Viral Infection
• Inflammasome activation in response to eukaryotic pathogens
• Inflammasome activation by pathogenic crystals and particles
• Inflammasome activation by danger signals
• Toll like receptors and inflammasomes
• Inflammasome in the skin
• Cancer, inflammasomes and adjuvanticity
• Inflammasome and lung pathologies
• Mechanisms of NLRP3 inflammasome activation in CAPS patients
• Activation and regulation of the NLRP3 inflammasome
• Treatment of inflammasome-related disorders.