Matrix Metalloproteinase Inhibitors Specificity of Binding and Structure-Activity Relationships /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Gupta, Satya Prakash (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Springer Basel, 2012.
• Series: Experientia Supplementum, 103
• Subjects: Medicine.; Neurosciences.; Biomedicine.

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results i...

Table of Contents:

• Matrix Metalloproteinases
• Specificity of Binding with Matrix Metalloproteinases
• The Gelatinases and Their Inhibitors: The Structure–Activity Relationships
• Advances in Studies on Collagenase Inhibitors
• Hydroxamic Acids as Matrix Metalloproteinase Inhibitors
• Quantitative Structure–Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors
• Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease.