Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials

• Main Authors: Kiang, Tony K.L (Author), Wilby, Kyle John (Author), Ensom, Mary H.H (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Adis, 2015.
• Subjects: Medicine.; Health promotion.; Tropical medicine.; Pharmacy.; Medicine & Public Health.; Tropical Medicine.; Health Promotion and Disease Prevention.; Drug Safety and Pharmacovigilance.

This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identifie...

Table of Contents:

• Introduction
• Pharmacology of Recommended Antimalarial Agents
• Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials
• Pharmacokinetic Drug Interactions Affecting Antimalarials
• Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs
• Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials
• Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions
• Limitations, Future Directions, and Conclusions.