Ubiquitin Chains: Degradation and Beyond

• Main Author: De, Arnab (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Life sciences.; Immunology.; Proteins.; Cell cycle.; Life Sciences.; Protein Science.; Cell Cycle Analysis.

This thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to d...

Table of Contents:

• 1 Immune homeostasis: Activation and Downregulation of NF-κB
• 2 Regulation of NF-κB signaling by regulatory ubiquitination: specific pathways and A20
• 3 The deubiquitinase activity of A20 is dispensable for its role in NF-κB signaling
• 4 Perspectives on regulatory ubiquitination.