Bone Toxicology

• Corporate Author: SpringerLink (Online service)
• Other Authors: Smith, Susan Y. (Editor), Varela, Aurore (Editor), Samadfam, Rana (Editor)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2017.
• Series: Molecular and Integrative Toxicology,
• Subjects: Medicine.; Pharmacology.; Pharmaceutical technology.; Animal models in research.; Biomedicine.; Pharmacology/Toxicology.; Pharmaceutical Sciences/Technology.; Animal Models.

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describ...

Table of Contents:

• Bone Toxicology in Preclinical Drug Testing
• Bone Physiology and Biology
• Study designs and Regulatory Considerations
• Specific Considerations for Bone Evaluations for Pediatric Therapeutics
• Bone Pharmacology and other models in Preclinical Drug Testing
• Methods in Bone Toxicology
• Biochemical Markers and Hormones
• Imaging
• Biomechanics
• Pathology and Histomorphometry
• Integrated System Toxicology
• Bone and Muscle
• Bone and Reproductive System
• Bone and Kidneys
• Bone and Energy Metabolism
• Bone and Immune System
• Bone and Central Nervous System
• Bone and Other Organs.