Resistance to Molecular Therapies for Hepatocellular Carcinoma
This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing : Imprint: Springer,
2017.
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| Series: | Resistance to Targeted Anti-Cancer Therapeutics,
13 |
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| Online Access: | Full Text via HEAL-Link |
| Summary: | This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies. |
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| Physical Description: | XIII, 147 p. 16 illus. in color. online resource. |
| ISBN: | 9783319561974 |
| ISSN: | 2196-5501 ; |
