A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

• Corporate Author: SpringerLink (Online service)
• Other Authors: Garcia-Reyero, Natàlia (Editor, http://id.loc.gov/vocabulary/relators/edt), Murphy, Cheryl A. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Subjects: Systems biology.; Pharmacology.; Systems Biology.; Pharmacology/Toxicology.

Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analyti...

Table of Contents:

• 1. Introduction
• Part I: Biology
• 2. "Non-model" species for eco and human health risk assessment
• 3.The fish embryo as a model  for eco-toxicology and other potential models
• 4.Invertebrates/Plants
• 5.Behavioral/Neurobehavioral linkages to AOPs
• 6. Species extrapolation - common pathways etc
• 7.  Life History Evolution, incorporating evolutionary processes into AOPs to extrapolate
• Part II: Incorporating Biology into AOPs
• 8.Use of HTS assays to infer MIEs
• 9. AOP development: how to infer and define KER
• 10. The development of quantitative AOPs
• Part IV: Incorporating Modeling into AOPs.-11.Computational approaches (network science, etc) in AOPs: linking molecular datasets
• 12.Computational approaches : Dynamic Energy Budgets
• 13.  Modeling approaches in AOPs: extrapolation from individual to population
• 14.  Modeling approaches that augment AOPs: GUTS, QSAR, TKTD PBTKTD
• 15.  Exposure science and other stressors? How to incorporate
• 16.  AOP as an organizing framework and implications for biological science-AOP evolution
• 17. Use and acceptance of AOPs for regulatory applications, use of AOPs in human risk assessment, and legislation. .