Targeting the DNA Damage Response for Anti-Cancer Therapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Pollard, John (Editor, http://id.loc.gov/vocabulary/relators/edt), Curtin, Nicola (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Humana, 2018.
• Edition: 1st ed. 2018.
• Series: Cancer Drug Discovery and Development,
• Subjects: Cancer research.; Gene therapy.; Cancer Research.; Gene Therapy.

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has als...