Molecular Mechanisms of Notch Signaling

• Corporate Author: SpringerLink (Online service)
• Other Authors: Borggrefe, Tilman (Editor, http://id.loc.gov/vocabulary/relators/edt), Giaimo, Benedetto Daniele (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Advances in Experimental Medicine and Biology, 1066
• Subjects: Proteins .; Receptors.; Protein-Ligand Interactions.; Protein Structure.

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular...

Table of Contents:

• Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis
• Structural insights into Notch receptor-ligand interactions
• The Molecular Mechanism of Notch Activation
• Regulation of Notch Function by O-Glycosylation
• Modeling the Notch response
• Endocytic trafficking of the Notch receptor
• The Notch Interactome: complexity in signaling circuitry
• Integration of Drosophila and Human Genetics to understand Notch signaling related diseases
• Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a Notch?
• The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms
• Notch and neurogenesis
• Notch and stem cells
• Oscillatory control of Notch signaling in development
• CSL-associated corepressor and coactivator complexes
• Notch and senescence
• Control of blood vessel formation by Notch signaling
• Notch and T cell function - a complex tale
• Notch in leukemia.