Animal Models of T Cell-Mediated Skin Diseases

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Zollner, T. (Επιμελητής έκδοσης), Renz, H. (Επιμελητής έκδοσης), Asadullah, K. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg, 2005.
• Σειρά: Ernst Schering Research Foundation Workshop, 50
• Θέματα: Chemistry.; Medicinal chemistry.; Dermatology.; Internal medicine.; Respiratory organs > Diseases.; Cell biology.; Medicinal Chemistry.; Biomedicine general.; Cell Biology.; Pneumology/Respiratory System.; Internal Medicine.
• Φυσική περιγραφή: XIII, 291 p. online resource.
• ISBN: 9783540268116
• ISSN: 0947-6075 ;

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.