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03759nam a22005295i 4500 |
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978-3-540-69039-9 |
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DE-He213 |
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20151116132725.0 |
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cr nn 008mamaa |
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100301s2009 gw | s |||| 0|eng d |
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|a 9783540690399
|9 978-3-540-69039-9
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|a 10.1007/978-3-540-69039-9
|2 doi
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|a 615.19
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|a Tubulin-Binding Agents
|h [electronic resource] :
|b Synthetic, Structural and Mechanistic Insights /
|c edited by Teresa Carlomagno.
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|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 2009.
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|a XI, 331 p.
|b online resource.
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|a text
|b txt
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|a computer
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|a text file
|b PDF
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|a Topics in Current Chemistry,
|x 0340-1022 ;
|v 286
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|a Macrolide-Based Microtubule-Stabilizing Agents – Chemistry and Structure–Activity Relationships -- The Chemical Synthesis of Discodermolide -- The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels -- The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR -- The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography -- Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin -- Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents.
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|a reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.
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|a Chemistry.
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|a Cancer research.
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|a Analytical chemistry.
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|a Organic chemistry.
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|a Medicinal chemistry.
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|a Biochemistry.
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|a Chemistry.
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|a Medicinal Chemistry.
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|a Biochemistry, general.
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|a Cancer Research.
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| 650 |
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|a Organic Chemistry.
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| 650 |
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|a Analytical Chemistry.
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|a Carlomagno, Teresa.
|e editor.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783540690368
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| 830 |
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|a Topics in Current Chemistry,
|x 0340-1022 ;
|v 286
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|u http://dx.doi.org/10.1007/978-3-540-69039-9
|z Full Text via HEAL-Link
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|a ZDB-2-CMS
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| 950 |
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|a Chemistry and Materials Science (Springer-11644)
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