Tubulin-Binding Agents Synthetic, Structural and Mechanistic Insights /
reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year pe...
Συγγραφή απο Οργανισμό/Αρχή: | |
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Άλλοι συγγραφείς: | |
Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2009.
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Σειρά: | Topics in Current Chemistry,
286 |
Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Macrolide-Based Microtubule-Stabilizing Agents – Chemistry and Structure–Activity Relationships
- The Chemical Synthesis of Discodermolide
- The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels
- The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR
- The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography
- Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin
- Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents.