Targeting Functional Centers of the Ribosome

• Main Author: Davidovich, Chen (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011.
• Series: Springer Theses
• Subjects: Life sciences.; Organic chemistry.; Nucleic acids.; Proteins.; Life Sciences.; Nucleic Acid Chemistry.; Protein Science.; Organic Chemistry.

This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combin...