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02402nam a22004815i 4500 |
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978-3-642-16931-1 |
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DE-He213 |
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20151204182212.0 |
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110201s2011 gw | s |||| 0|eng d |
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|a 9783642169311
|9 978-3-642-16931-1
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|a 10.1007/978-3-642-16931-1
|2 doi
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|a QD433-436
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|a SCI007000
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|a 572.84
|2 23
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|a Davidovich, Chen.
|e author.
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|a Targeting Functional Centers of the Ribosome
|h [electronic resource] /
|c by Chen Davidovich.
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|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg,
|c 2011.
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|a XIV, 74 p.
|b online resource.
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|a text
|b txt
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|a computer
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|a online resource
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|a text file
|b PDF
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|a Springer Theses
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|a Introduction -- Methods -- Results -- Discussion.
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|a This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
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|a Life sciences.
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|a Organic chemistry.
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|a Nucleic acids.
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|a Proteins.
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|a Life Sciences.
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|a Nucleic Acid Chemistry.
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|a Protein Science.
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|a Organic Chemistry.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9783642169304
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|a Springer Theses
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|u http://dx.doi.org/10.1007/978-3-642-16931-1
|z Full Text via HEAL-Link
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|a ZDB-2-SBL
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|a Biomedical and Life Sciences (Springer-11642)
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