Coarse-Grained Modelling of DNA and DNA Self-Assembly

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of s...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Ouldridge, Thomas E. (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012.
Σειρά:Springer Theses, Recognizing Outstanding Ph.D. Research,
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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100 1 |a Ouldridge, Thomas E.  |e author. 
245 1 0 |a Coarse-Grained Modelling of DNA and DNA Self-Assembly  |h [electronic resource] /  |c by Thomas E. Ouldridge. 
264 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg :  |b Imprint: Springer,  |c 2012. 
300 |a XII, 176 p.  |b online resource. 
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490 1 |a Springer Theses, Recognizing Outstanding Ph.D. Research,  |x 2190-5053 
505 0 |a A Novel DNA Model -- Methods -- Finite Size Effects -- Structural and Mechanical Properties of Model DNA -- Thermodynamic Properties of Model DNA -- Modelling DNA Tweezers -- Modelling a DNA Walker. 
520 |a This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology. 
650 0 |a Physics. 
650 0 |a Polymers. 
650 0 |a Amorphous substances. 
650 0 |a Complex fluids. 
650 0 |a Biophysics. 
650 0 |a Biological physics. 
650 0 |a Statistical physics. 
650 0 |a Dynamical systems. 
650 0 |a Nanotechnology. 
650 1 4 |a Physics. 
650 2 4 |a Biophysics and Biological Physics. 
650 2 4 |a Nanotechnology. 
650 2 4 |a Polymer Sciences. 
650 2 4 |a Statistical Physics, Dynamical Systems and Complexity. 
650 2 4 |a Soft and Granular Matter, Complex Fluids and Microfluidics. 
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776 0 8 |i Printed edition:  |z 9783642305160 
830 0 |a Springer Theses, Recognizing Outstanding Ph.D. Research,  |x 2190-5053 
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950 |a Physics and Astronomy (Springer-11651)