Regulatory T Cells in Inflammation

• Corporate Author: SpringerLink (Online service)
• Other Authors: Taams, Leonie S. (Editor), Wauben, Marca H. M. (Editor), Akbar, Arne N. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Basel : Birkhäuser Basel, 2005.
• Series: Progress in Inflammation Research
• Subjects: Medicine.; Immunology.; Pharmacology.; Internal medicine.; Endocrinology.; Cell biology.; Biomedicine.; Pharmacology/Toxicology.; Internal Medicine.; Cell Biology.

Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses...

Table of Contents:

• Origin, function and distribution of regulatory T cells
• History of CD25+CD4+ regulatory T cells
• “Natural” and “induced” regulatory T cells — purpose and problems associated with an emerging distinction
• The role of interleukin-10 in regulatory-T-cell suppression: reconciling the discrepancies
• Activation and distribution of regulatory T cells in naïve and antigen-stimulated immune systems
• Regulatory T cells and the innate immune system
• The potential use of regulatory T cells in immunotherapy
• Exploiting the potential of regulatory T cells in the control of type 1 diabetes
• Regulatory T cells in type 1 autoimmune diabetes
• The potential for targeting CD4+CD25+ regulatory T cells in the treatment of multiple sclerosis in humans
• Immunotherapy of rheumatoid arthritis using CD4+CD25+ regulatory T cells
• Potential for manipulation of regulatory T cells in treatment or prevention of allergic disease
• The role of regulatory T cells in cutaneous disorders
• The potential role of CD25+CD4+ regulatory T cells in the induction and maintenance of transplantation tolerance in humans.