Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia
Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, diagnosis, a...
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| Format: | Electronic eBook |
| Language: | English |
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Tokyo :
Springer Japan : Imprint: Springer,
2016.
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| Edition: | 1st ed. 2016. |
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| Online Access: | Full Text via HEAL-Link |
Table of Contents:
- 1. Identification and Biology of CML Stem Cells.- 2. Molecular Mechanisms of CML Stem Cell Maintenance
- 3. Roles for Signaling Molecules in the Growth and Survival of CML Cells.- 4. Goal of CML Treatment in the Tyrosine Kinase Inhibitor Era.- 5. Biomarkers for Determining the Prognosis of CML
- 6. Updated European Leukemia Net Recommendations for the Management of CML
- 7. Optimal Monitoring of CML Treatment: Molecular and Mutation Analysis
- 8. Recommendations for Management of CML in the Era of Second-Generation TKIs
- 9. Role of New TKIs and Combinations with Interferon-α for the Treatment of CML
- 10. Safety Profiles of First-Line TKIs and Managing Adverse Effects
- 11. Molecular Mechanism of TKI Resistance and Potential Approaches to Overcome Resistance
- 12. Discontinuation of Therapy and Treatment-Free Remission in CML.
