Endotoxins: Structure, Function and Recognition

• Corporate Author: SpringerLink (Online service)
• Other Authors: Wang, Xiaoyuan (Editor), Quinn, Peter J. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2010.
• Series: Subcellular Biochemistry, 53
• Subjects: Medicine.; Immunology.; Medical microbiology.; Pharmacology.; Infectious diseases.; Biomedicine.; Medical Microbiology.; Infectious Diseases.; Pharmacology/Toxicology.

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis,...

Table of Contents:

• I Structure and Properties of Endotoxins
• Endotoxins: Lipopolysaccharides of Gram-Negative Bacteria
• Purification and Characterization of Lipopolysaccharides
• Endotoxins: Relationship Between Structure, Function, and Activity
• The Diversity of the Core Oligosaccharide in Lipopolysaccharides
• Salmonella-Regulated Lipopolysaccharide Modifications
• The Variation of O Antigens in Gram-Negative Bacteria
• Regulators of TLR4 Signaling by Endotoxins
• Membrane Partitioning: Is Location Everything When It Comes to Endotoxin Recognition?
• Infection, Treatment and Immunity
• Endotoxin Detection – from Limulus Amebocyte Lysate to Recombinant Factor C
• The Role of Endotoxin in Infection: Helicobacter pylori and Campylobacter jejuni
• The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infection
• Development of Small-Molecule Endotoxin Sequestering Agents
• Development of an Anti-Endotoxin Vaccine for Sepsis
• Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants
• Targeting Endotoxin in the Treatment of Sepsis
• Lipopolysaccharides in Rhizobium-Legume Symbioses
• Lipopolysaccharides and Plant Innate Immunity.