A Structural Perspective on Respiratory Complex I Structure and Function of NADH:ubiquinone oxidoreductase /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Sazanov, Leonid (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands, 2012.
• Θέματα: Medicine.; Molecular biology.; Biochemistry.; Proteins.; Cell membranes.; Biomedicine.; Biomedicine general.; Biochemistry, general.; Protein Structure.; Membrane Biology.; Molecular Medicine.

Complex I (NADH:ubiquinone oxidoreductase) is the first and largest enzyme of the respiratory chain in mitochondria and plays a central role in cellular energy production. Complex I dysfunction has been implicated in many human neurodegenerative diseases, including Parkinson’s. Mutations in complex...