A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kulkarni, Vishwesh V. (Editor), Stan, Guy-Bart (Editor), Raman, Karthik (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2014.
• Subjects: Medicine.; Pharmaceutical technology.; Bioinformatics.; Systems biology.; Biomathematics.; Applied mathematics.; Engineering mathematics.; Biomedicine.; Biomedicine general.; Computational Biology/Bioinformatics.; Systems Biology.; Mathematical and Computational Biology.; Pharmaceutical Sciences/Technology.; Appl.Mathematics/Computational Methods of Engineering.

The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is...

Table of Contents:

• 1 On the Mathematics of the Law of Mass Action
• 2 Structural Analysis of Biological Networks
• 3 Guaranteeing Spatial Uniformity in Reaction-Diffusion Systems Using Weighted L2-norm Contractions
• 4 Robust Tunable Transcriptional Oscillators using Dynamic Inversion
• 5 Towards the Modular Decomposition of the Metabolic Network
• 6 An Optimal Control Approach to Seizure Detection in Drug-Resistant Epilepsy
• 7 Model Reduction of Genetic-Metabolic Networks via Time-Scale Separation
• 8 Networks, Metrics, and Systems Biology
• 9 Understanding and Predicting Biological Networks Using Linear System Identification
• 10 Model Checking in Biology
• 11 Computational Design of Informative Experiments in Systems Biology
• 12 Predicting Phenotype from Genotype through Reconstruction and Integrative Modeling of Metabolic and Regulatory Networks
• Index.