Cellular Osmolytes From Chaperoning Protein Folding to Clinical Perspectives /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Rajendrakumar Singh, Laishram (Editor), Dar, Tanveer Ali (Editor)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2017.
• Subjects: Medicine.; Cancer research.; Biomedical engineering.; Biochemistry.; Plant biochemistry.; Proteins.; Cell physiology.; Biomedicine.; Biomedical Engineering/Biotechnology.; Cell Physiology.; Protein-Ligand Interactions.; Cancer Research.; Animal Biochemistry.; Plant Biochemistry.

This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. Even a subtle change in the composition of the solvent environme...

Table of Contents:

• Polyols as exceptional Protein stabilizers
• Osmolyte mixtures versus individuals in protein folding and aggregation
• Molecular insights of Osmolyte-protein Interaction
• MDS simulation studies on osmolyte protein interactions
• Osmolytes as protein aggregation Modifiers
• Osmolytes as Nano-probes of conformational changes
• Inhibition of Protein fibrillation by Chemical chaperones: a Therapeutic strategy
• Osmolyte in Infectious Diseases
• Possible strategies for the therapeutic intervention of osmolyte in Cancer
• Antioxidant osmolytes
• Advances on the in vivo studies of the effect of osmolyte on various pathophysiological conditions
• TMAO in alpha Synuclein aggregation
• Osmolytes: from cell physiology to Disease Prevention
• Osmolytes in Cell-volume Regulation
• Role of Osmolytes in counteracting the deleterious effects of denaturant/pressure.